子宫腺肌病炎症指标和凝血指标的变化及其意义  

Changes of inflammatory index and coagulation index in adenomyosis and their significance

作　　者：茅娅男 倪涓涓[1] MAO Ya'nan;NI Juanjuan(Department of Obstetrics and Gynecology,Affiliated Hospital of Nantong University,Nantong,Jiangsu 226000,China)

机构地区：[1]南通大学附属医院妇产科,江苏南通226000

出　　处：《医药前沿》2025年第11期69-71,共3页Journal of Frontiers of Medicine

摘　　要：目的探讨子宫腺肌病炎症指标和凝血指标的变化及其临床意义。方法选取2021年10月—2023年10月南通大学附属医院收治的单纯性子宫腺肌病的患者118例纳入观察组,选取同期单纯性子宫内膜息肉患者155例纳入对照组。将118例子宫腺肌病患者以血红蛋白110 g/L为界分为贫血组(64例)及非贫血组(54例)。比较观察组和对照组、贫血组与非贫血组的炎症指标及凝血指标变化。结果观察组的相关炎症指标白细胞计数、中性粒细胞计数、中性粒细胞百分比(NE%)、中性粒细胞与淋巴细胞比值(NLR)及血小板与淋巴细胞比值(PLR)均高于对照组(P<0.05),相关凝血指标仅有血小板计数(PLT)高于对照组(P<0.05)。贫血组的炎症指标NE%、NLR及PLR均高于非贫血组(P<0.05);贫血组的PLT高于非贫血组,且活化部分凝血活酶时间较非贫血组缩短(P<0.05)。结论子宫腺肌病患者会处于高炎症反应及以血小板升高为主的高凝状态,在贫血患者中更为明显,提示月经量过多可能促进炎症及凝血功能的改变。因此,对子宫腺肌病患者应进行血栓风险管理以指导合理用药。Objective To investigate the changes of inflammatory indexes and coagulation indexes in adenomyosis and their clinical significance.Methods A total of 118 patients with simple adenomyosis admitted to the Affiliated Hospital of Nantong University from October 2021 to October 2023 were selected as the observation group,and 155 patients with simple endometrial polyps during the same period were selected as the control group.Further,118 patients with adenomyosis were divided into anemia group(64 cases)and non-anemia group(54 cases)according to hemoglobin 110 g/L,and the changes of inflammatory indexes and coagulation indexes between observation group and control group,anemia group and non-anemia group were compared.Results The inflammatory indexes such as white blood cell count,neutrophil count,neutrophil percentage(NE%),neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)in observation group were significantly higher than those in control group(P<0.05),and only the platelet count(PLT)was higher than that in control group(P<0.05).Inflammatory indexes such as NE%,NLR and PLR in anemia group were significantly higher than those in non-anemia group(P<0.05).The PLT of anemia group was higher than that of non-anemia group,and the activation time of partial thromboplastin was shorter than that of non-anemia group(P<0.05).Conclusions Patients with adenomyosis may be in a hypercoagulable state with high inflammatory and platelet elevation,which is more obvious in anemia patients,suggesting that excessive menstrual volume may promote inflammatory and coagulation function changes.Therefore,thrombotic risk management should be carried out in patients with adenomyosis to guide rational drug use.

关 键 词：子宫腺肌病 炎症 凝血 血小板 贫血 

分 类 号：R711[医药卫生—妇产科学]