复方甘草酸苷联合常规抗病毒药物治疗乙型肝炎肝硬化患者的效果观察  

Observation on the effect of Compound Glycyrrhizin combined with conventional antiviral drugs in the treatment of patients with hepatitis B cirrhosis

作　　者：郝志民 HAO Zhimin(Department of Infectious Diseases,Heze Hospital of Traditional Chinese Medicine,Heze,Shandong 274500,China)

机构地区：[1]菏泽市中医医院感染性疾病科,山东菏泽274500

出　　处：《医药前沿》2025年第11期72-74,78,共4页Journal of Frontiers of Medicine

摘　　要：目的观察复方甘草酸苷联合常规抗病毒药物治疗乙型肝炎肝硬化患者的效果。方法选取2021年1月—2023年1月菏泽市中医医院收治的乙型肝炎肝硬化患者84例,按照治疗方法分为观察组和对照组,各42例。对照组采用常规抗病毒药物治疗,观察组在对照组治疗基础上联合复方甘草酸苷片治疗。比较两组临床疗效、乙型肝炎e抗原(HBeAg)转阴率、乙型肝炎病毒(HBV)转阴率、肝纤维化指标、氧化应激指标及不良反应发生情况。结果治疗1年后,观察组总有效率、HBeAg转阴率及HBV转阴率高于对照组;Ⅲ型前胶原、Ⅳ型胶原透明质酸、层黏连蛋白、丙二醛及黄嘌呤氧化酶水平低于对照组(P<0.05)。治疗期间,两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论复方甘草酸苷联合常规抗病毒药物治疗乙型肝炎肝硬化患者的效果显著,可有效提高HBeAg及HBV转阴率,改善肝纤维化及氧化应激指标水平,且安全性较高。Objective To observe the effect of Compound Glycyrrhizin combined with conventional antiviral drugs in the treatment of patients with hepatitis B cirrhosis.Methods A total of 84 patients with hepatitis B cirrhosis admitted to Heze Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were selected and divided into observation group and control group according to the treatment method,with 42 cases in each group.The control group was treated with conventional antiviral drugs,and the observation group was treated with Compound Glycyrrhizin Tablets on the basis of the control group.The clinical efficacy,hepatitis B e antigen(HBeAg)negative conversion rate,hepatitis B virus(HBV)negative conversion rate,liver fibrosis index,oxidative stress index and adverse reactions were compared between the two groups.Results After 1 year of treatment,the total effective rate,HBeAg negative conversion rate and HBV negative conversion rate in the observation group were higher than those in the control group.The levels of procollagenⅢpeptide,type IV collagen hyaluronic acid,laminin,malondialdehyde and xanthine oxidase were lower than those in the control group,and the differences were statistically significant(P<0.05).During the treatment,there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions Compound Glycyrrhizin combined with conventional antiviral drugs has a significant effect in the treatment of patients with hepatitis B cirrhosis,which can effectively improve the negative conversion rate of HBeAg and HBV,improve the level of liver fibrosis and oxidative stress index,and has high safety.

关 键 词：乙型肝炎肝硬化 复方甘草酸苷 乙型肝炎病毒 Ⅲ型前胶原 层黏连蛋白 丙二醛 不良反应 

分 类 号：R657[医药卫生—外科学]