阻塞性睡眠呼吸暂停低通气综合征与脑白质病变的相关性研究  

Association between obstructive sleep apnea hypopnea syndrome and cerebral white matter lesions

作　　者：王源 王丹 贺嘉[1] 勾海燕[1] 陈岩[1] 石佳琦 曲悠扬[1] 朱雨岚[1] 朱延梅[1] WANG Yuan;WANG Dan;HE Jia(The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150000 [2]齐齐哈尔医学院附属第三医院,黑龙江齐齐哈尔161000

出　　处：《中风与神经疾病杂志》2025年第3期204-208,F0003,共6页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与脑白质病变(WMLs)的关系。方法筛选2019年6月—2020年12月于哈尔滨医科大学附属第二医院神经内科、癫痫及睡眠障碍科就诊的符合WMLs诊断标准的患者91例及无WMLs的对照组61例,对全部受试者进行头部MRI检查、PSG检查,收集患者人口学、既往史、个人史、实验室检查及影像学检查等结果资料。结果WMLs组罹患OSAHS的比率为92.3%、PSG检查结果中AHI指数为(32.85±19.86)次/h,高于对照组(P<0.05)。Spearman秩相关统计分析结果显示,WMLs严重程度与OSAHS严重程度之间存在正向较强相关性(r=0.60252,P<0.0001)。结论WMLs组与对照组比较更易罹患OSAHS;WMLs严重程度与OSAHS严重程度存在正向较强相关性。Objective To investigate the association between obstructive sleep apnea hypopnea syndrome(OSAHS)and white matter lesions(WMLs).Methods A total of 91 patients who attended Department of Neurology and Department of Epilepsy and Sleep Disorders in The Second Affiliated Hospital of Harbin Medical University from June 2019 to December 2020 and met the diagnostic criteria for WMLs were enrolled as WMLs group,and 61 patients without WMLs were enrolled as control group.All subjects underwent brain MRI and PSG examinations,and related data were collected,including demographic data,past history,personal history,laboratory examination,and imaging findings.Results The WMLs group had a prevalence rate of OSAHS of 92.3%and an AHI of(32.85±19.86)events/hour on PSG,which were significantly higher than those in the control group(P<0.05).The Spearman rank correlation analysis showed a strong positive correlation between WMLs severity and OSAHS severity(r=0.60252,P<0.0001).Conclusion The WMLs group is more susceptible to OSAHS than the control group,and the severity of WMLs is positively correlated with the severity of OSAHS.

关 键 词：脑白质病变 阻塞性睡眠呼吸暂停低通气综合征 脑小血管疾病 腔隙性梗死 脑微出血 

分 类 号：R563.8[医药卫生—呼吸系统] R743[医药卫生—内科学]