盐酸氨溴索加阿奇霉素在小儿肺炎中的应用效果及对CD4^(+)、IgA水平的影响  

The Application Effect of Ambroxol Hydrochloride and Azithromycin in Children with Pneumonia and Its Influence on CD4^(+)and IgA Levels

作　　者：郭宏 徐冉 GUO Hong;XU Ran(Department of Pediatrics,Dehong People's Hospital of Yunnan Province,Dehong,Yunnan,678400,China)

机构地区：[1]云南省德宏州人民医院儿科,云南德宏678400

出　　处：《中外医疗》2025年第7期17-20,共4页China & Foreign Medical Treatment

摘　　要：目的分析盐酸氨溴索联合阿奇霉素在小儿肺炎中的应用效果及对CD4^(+)、免疫球蛋白A(immuno⁃globulin A,IgA)的影响。方法随机选取2023年1—12月云南省德宏州人民医院收治的120例肺炎患儿为研究对象,根据不同治疗方法分为对照组(n=60,单纯阿奇霉素治疗)、联合组(n=60,盐酸氨溴索联合阿奇霉素治疗),对比两组的临床疗效、症状消失时间、炎性因子水平、免疫指标及不良反应发生情况。结果联合组治疗总有效率为98.33%(59/60),低于对照组的83.33%(50/60),差异有统计学意义(χ^(2)=8.107,P<0.05)。联合组肺部啰音消失时间、气喘咳嗽消失时间、退热时间均短于对照组,差异均有统计学意义(P均<0.05)。治疗后,联合组白细胞介素-6、C-反应蛋白水平均低于对照组,CD4^(+)、IgA水平均高于对照组,差异均有统计学意义(P均<0.05)。联合组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论联合用药的治疗方案能够加速患儿康复,提升临床治疗效果,且不良反应较小。Objective To analyze the application effect of ambroxol hydrochloride combined with azithromycin in children with pneumonia and its effect on CD4^(+)and immunoglobulin A(IgA).Methods A total of 120 children with pneumonia admitted to Dehong People's Hospital of Yunnan Province from January to December 2023 were randomly selected as the research objects.According to different treatment methods,they were divided into control group(n=60,treated with azithromycin alone)and combined group(n=60,treated with ambroxol hydrochloride combined with azithromycin).The clinical efficacy,symptom disappearance,inflammatory factor levels,immune indexes and adverse reactions of the two groups were compared.Results The total effective rate of treatment in the combined group was 98.33%(59/60),which was lower than 83.33%(50/60)in the control group,and the difference was statistically significant(χ^(2)=8.107,P<0.05).The disappearance time of pulmonary rales,disappearance time of asthma and cough,and antipyretic time in the combined group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of interleukin-6 and C-reactive protein in the combined group were lower than those in the control group,and the levels of CD4^(+)and IgA were higher than those in the control group,the differences were statistically significant(all P<0.05).The total incidence of adverse reactions in the combined group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The treatment plan of combined medication can accelerate the recovery of children,improve the clinical treatment effect,and have less adverse reactions.

关 键 词：盐酸氨溴索 阿奇霉素 小儿肺炎 临床效果 免疫指标 

分 类 号：R725.6[医药卫生—儿科]