乌美溴铵维兰特罗联合无创呼吸机对慢性阻塞性肺疾病合并呼吸衰竭患者的疗效  

Therapeutic Effect of Combination of Umeclidinium Bromide and Vilanterol Trifenatate and Noninvasive Ventilator on Chronic Obstructive Pulmonary Disease Patients with Respiratory Failure

作　　者：郭芳惠 徐仰玲 齐鲁钰 GUO Fanghui;XU Yangling;QI Luyu(Department of Respiratory and Critical Care Medicine,Liaocheng Infectious Disease Hospital,Liaocheng,Shandong,252000,China;Department of Tuberculosis,Liaocheng Infectious Disease Hospital,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市传染病医院呼吸与危重症医学科,山东聊城252000 [2]聊城市传染病医院结核科,山东聊城252000

出　　处：《中外医疗》2025年第7期30-34,共5页China & Foreign Medical Treatment

摘　　要：目的探究在对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并呼吸衰竭患者治疗时按照乌美溴铵维兰特罗联合无创呼吸机进行治疗的效果。方法方便选取2020年1月—2022年6月聊城市传染病医院收治的108例COPD合并呼吸衰竭患者为研究对象,根据不同治疗方法分为对照组、观察组,各54例。对照组开展常规治疗,观察组开展乌美溴铵维兰特罗联合无创呼吸机治疗。对比两组肺功能、血气指标、呼吸功能、症状改善时间及住院时间、免疫功能。结果治疗后,观察组第1秒用力呼气量/用力肺活量、用力肺活量、峰值流速均高于对照组,差异均有统计学意义(P均<0.05)。治疗后,观察组氧合指数、血氧分压均高于对照组,二氧化碳分压低于对照组,差异均有统计学意义(P均<0.05)。治疗后,观察组呼吸系统静态顺应性(20.68±1.25)mL/cmH_(2)O高于对照组的(16.74±1.75)mL/cmH_(2)O,平台压(10.68±1.05)cmH_(2)O低于对照组的(13.45±1.15)cmH_(2)O,差异均有统计学意义(t=13.463,13.071;P均<0.05)。观察组肺啰音改善时间、咳嗽消失时间、咳痰消失时间、住院时间均短于对照组,差异均有统计学意义(P均<0.05)。治疗后,观察组免疫功能水平优于对照组,差异有统计学意义(P<0.05)。结论在对COPD合并呼吸衰竭患者治疗过程中按照乌美溴铵维兰特罗联合无创呼吸机进行治疗,可以促使患者肺功能得到提升,改善患者血气水平,提升患者呼吸功能,促使患者各方面症状迅速改善。Objective To explore the effect of umeclidinium bromide and vilanterol trifenatate combined with noninvasive ventilator in the treatment of patients with chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.Methods A total of 108 patients with COPD complicated with respiratory failure admitted to Liaocheng Infectious Disease Hospital from January 2020 to June 2022 were conveniently selected as the research objects.According to different treatment methods,they were divided into control group and observation group.The control group was treated with routine treatment,and the observation group was treated with umeclidinium bromide and vilanterol trifenatate combined with non-invasive ventilator.The lung function level,blood gas level,respiratory function,symptom improvement time,hospitalization time and immune function level were compared between the two groups.Results After treatment,the forced expiratory volume in the first second/forced vital capacity,forced vital capacity and peak flow rate in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the oxygenation index and partial pressure of blood oxygen in the observation group were higher than those in the control group,and the partial pressure of carbon dioxide was lower than that in the control group,the differences were statistically significant(all P<0.05).After treatment,the static compliance of the respiratory system in the observation group(20.68±1.25)mL/cmH_(2)O was higher than that in the control group(16.74±1.75)mL/cmH_(2)O,and the platform pressure(10.68±1.05)cmH_(2)O was lower than that in the control group(13.45±1.15)cmH_(2)O,the differences were statistically significant(t=13.463,13.071;both P<0.05).The improvement time of pulmonary rales,cough disappearance time,expectoration disappearance time and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically

关 键 词：乌美溴铵维兰特罗 无创呼吸机 慢性阻塞性肺疾病 呼吸衰竭 肺功能 

分 类 号：R5[医药卫生—内科学]