地屈孕酮与戊酸雌二醇联合治疗对围绝经期功能失调性子宫出血的临床疗效  

Clinical Efficacy of Dydrogesterone Combined with Estradiol Valerate in the Treatment of Perimenopausal Dysfunctional Uterine Bleeding

作　　者：陈晓燕 陈巧丽 罗惠珊 CHEN Xiaoyan;CHEN Qiaoli;LUO Huishan(Department of Pharmacy,Yongchun Maternal and Child Health Hospital,Quanzhou,Fujian,362000,China;Pharmacy,Jiefu Branch of Yongchun General Hospital,Quanzhou,Fujian,362602,China;Pharmacy,Wufeng Health Center of Yongchun County,Quanzhou,Fujian,362602,China)

机构地区：[1]福建省泉州市永春县妇幼保健院药剂科,福建泉州362000 [2]福建省泉州市永春县总医院介福分院药房,福建泉州362602 [3]福建省泉州市永春县吾峰卫生院药房,福建泉州362602

出　　处：《中外医疗》2025年第7期52-55,65,共5页China & Foreign Medical Treatment

摘　　要：目的研究地屈孕酮联合戊酸雌二醇治疗围绝经期功能失调性子宫出血的临床效果。方法回顾性选取2021年2月—2024年2月福建省泉州市永春县妇幼保健院收治的100例围绝经期功能失调性子宫出血患者的临床资料,根据不同治疗方法分组。单一组(n=50)予戊酸雌二醇治疗,联合组(n=50)联合地屈孕酮治疗,比较两组的症状缓解指标、性激素水平、治疗效果及不良反应。结果治疗后,联合组子宫内膜厚度、月经量、血红蛋白水平及完全止血时间均优于单一组,差异均有统计学意义(P均<0.05)。治疗后相较于单一组,联合组性激素水平更优,差异有统计学意义(P<0.05)。治疗总有效率对比,联合组的96.00%(48/50)高于单一组的84.00%(42/50),差异有统计学意义(χ^(2)=4.000,P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用地屈孕酮联合戊酸雌二醇治疗围绝经期功能失调性子宫出血能够更好地缓解临床症状,不良反应发生率较低。Objective To study the clinical effect of dydrogesterone combined with estradiol valerate in the treatment of perimenopausal dysfunctional uterine bleeding.Methods The clinical data of 100 patients with perimenopausal dysfunctional uterine bleeding admitted to Yongchun Maternal and Child Health Hospital of Quanzhou City,Fujian Province from February 2021 to February 2024 were retrospectively selected.Grouped according to different treatment methods.The single group(n=50)was treated with estradiol valerate,and the combined group(n=50)was treated combined with dydrogesterone.The symptom relief indexes,sex hormone levels,therapeutic effects and adverse reactions were compared between the two groups.Results After treatment,the endometrial thickness,menstrual volume,hemoglobin level and complete hemostasis time in the combined group were better than those in the single group,and the differences were statistically significant(all P<0.05).After treatment,compared with the single group,the sex hormone level of the combined group was better,and the difference was statistically significant(P<0.05).The total effective rate of the combined group was 96.00%(48/50)higher than that of the single group 84.00%(42/50),and the difference was statistically significant(χ^(2)=4.000,P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The use of dydrogesterone combined with estradiol valerate in the treatment of perimenopausal dysfunctional uterine bleeding can better alleviate clinical symptoms,and the incidence of adverse reactions was low.

关 键 词：围绝经期 功能失调性子宫出血 戊酸雌二醇 地屈孕酮 联合治疗 临床疗效 

分 类 号：R71[医药卫生—妇产科学]