硫酸氢氯吡格雷联合小剂量西洛他唑治疗下肢动脉硬化闭塞症的临床效果  

Clinical Effect of Clopidogrel Hydrogen Sulfate Combined with Low-dose Cilostazol in the Treatment of Lower Limb Arteriosclerosis Obliterans

作　　者：高峰 张金铭 王田 王俊 GAO Feng;ZHANG Jinming;WANG Tian;WANG Jun(Department of Vascular Surgery,Jinan Beicheng Hospital,Jinan,Shandong,250031,China;Department of Gen-eral Surgery,Jinan Beicheng Hospital,Jinan,Shandong,250031,China)

机构地区：[1]济南北城医院血管外科,山东济南250031 [2]济南北城医院普外科,山东济南250031

出　　处：《中外医疗》2025年第7期71-75,共5页China & Foreign Medical Treatment

摘　　要：目的探讨硫酸氢氯吡格雷联合小剂量西洛他唑治疗下肢动脉硬化闭塞症的临床应用效果。方法方便选取2020年10月—2023年10月济南北城医院收治的92例下肢动脉硬化闭塞症患者为研究对象,依据患者所进行治疗方法的不同分为对照组和观察组,每组均包含46例。对照组采取硫酸氢氯吡格雷治疗,观察组在此基础上增加小剂量西洛他唑治疗,比较两组治疗效果、动脉硬化指标、血液流变学指标、不良反应情况。结果与对照组的78.26%(36/46)相比,观察组的治疗总有效率93.48%(43/46)较高,差异有统计学意义(χ^(2)=4.389,P<0.05)。在足背动脉血管内径、踝肱指数、血流量、血流速度峰值方面,治疗前两组比较,差异均无统计学意义(P均>0.05)。治疗后,两组上述指标均升高,且观察组高于对照组,差异均有统计学意义(P均<0.05)。在血细胞比容、全血高切黏度、红细胞变形指数、红细胞聚集指数、血浆黏度方面,治疗前两组比较,差异均无统计学意义(P均>0.05)。治疗后,两组上述指标均降低,且观察组低于对照组,差异均有统计学意义(P均<0.05)。不良反应总发生率组间对比,差异无统计学意义(P>0.05)。结论针对下肢动脉硬化闭塞症患者采取硫酸氢氯吡格雷联合小剂量西洛他唑治疗可取得良好的治疗效果,可有效消退症状,并进一步改善动脉硬化,而且不良反应少,安全性高。Objective To investigate the clinical efficacy of clopidogrel hydrogen sulfate combined with low-dose cilostazol in the treatment of arteriosclerosis obliterans of the lower limbs.Methods A total of 92 patients with arteriosclerosis obliterans of the lower limbs admitted to Jinan Beicheng Hospital from October 2020 to October 2023 were convenient to select as the research objects.According to the different treatment methods of the patients,they were divided into control group and observation group,and each group included 46 cases.The control group was treated with clopidogrel hydrogen sulfate,while the observation group was additionally treated with low-dose cilostazol on this basis.The treatment efficacy,arteriosclerosis indicators,hemorheological indicators,and adverse reactions of the two groups were compared.Results Compared with 78.26%(36/46)in the control group,the total effective rate of treatment in the observation group was 93.48%(43/46),which was higher and the difference was statistically significant(χ^(2)=4.389,P<0.05).There was no significant difference in the inner diameter of dorsal artery of foot,ankle-brachial index,blood flow and peak blood flow velocity between the two groups before treatment(all P>0.05).After treatment,the above indexes in the two groups increased,and those in the observation group were higher than the control group,and the differences were statistically significant(all P<0.05).There was no significant difference in hematocrit,high shear blood viscosity,deformity-index,red blood cell aggregation index and viscosity of plasma between the two groups before treatment(all P>0.05).After treatment,the above indexes in both groups decreased,and those in the observation group were lower than the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between patients in the two groups(P>0.05).Conclusion The treatment of patients with arteriosclerosis obliterans of the lo

关 键 词：下肢动脉硬化闭塞症 硫酸氢氯吡格雷 西洛他唑 治疗效果 血液流变学 不良反应 

分 类 号：R543.5[医药卫生—心血管疾病]