替罗非班联合经皮冠脉介入治疗急性ST段抬高型心肌梗死的效果  

Efficacy of Tirofiban Combined with Percutaneous Coronary Intervention in the Treatment of Acute ST Segment Elevation Myocardial Infarction

作　　者：刘俊[1] LIU Jun(Department of Cardiovascular Medicine,Jurong People's Hospital,Jurong,Jiangsu,212400,China)

机构地区：[1]句容市人民医院心血管内科,江苏句容212400

出　　处：《中外医疗》2025年第8期70-73,共4页China & Foreign Medical Treatment

摘　　要：目的评估替罗非班与经皮冠脉介入联合治疗急性ST段抬高型心肌梗死的临床应用效果。方法随机选取2019年1月—2023年12月句容市人民医院收治的90例急性ST段抬高型心肌梗死患者为研究对象,按照不同治疗方法进行分组,每组45例。对照组实行经皮冠脉介入术治疗,观察组则在对照组的基础上加入替罗非班联合治疗,比较两组磷酸肌酸激酶同工酶峰值(术后2 h)及其峰值时间、心脏功能指标、心血管事件发生情况。结果观察组磷酸肌酸激酶同工酶峰值(术后2 h)低于对照组,峰值时间短于对照组,差异均有统计学意义(P均<0.05)。治疗后,观察组心脏功能指标(左心室舒张末期内径、左心室射血分数、左心室后壁厚度及室间隔厚度)水平均优于对照组,差异均有统计学意义(P均<0.05)。观察组心血管事件发生率为4.44%(2/45),低于对照组的17.78%(8/45),差异有统计学意义(χ^(2)=4.050,P=0.044)。结论采用经皮冠脉介入术治疗急性ST段抬高型心肌梗死时,加入替罗非班联合治疗,可增强患者心脏功能,改善术后再灌注问题,降低不良心血管事件的发生。Objective To evaluate the clinical effect of tirofiban combined with percutaneous coronary intervention in the treatment of acute ST segment elevation myocardial infarction.Methods A total of 90 patients with acute ST segment elevation myocardial infarction admitted to Jurong People's Hospital from January 2019 to December 2023 were randomly selected as the research objects and divided into groups according to different treatment methods,with 45 cases in each group.The control group was treated with percutaneous coronary intervention,while the observation group was treated with tirofiban on the basis of the control group.The peak value of creatine phosphokinase isoenzyme(2 h after operation)and its peak time,cardiac function index and cardiovascular events were compared between the two groups.Results The peak value of creatine phosphate isoenzyme(2 h after operation)in the observation group was lower than that in the control group,and the peak time was shorter than that in the control group,the differences were statistically significant(both P<0.05).After treatment,the levels of cardiac function indexes(left ventricular enddiastolic diameter,left ventricular ejection fraction,left ventricular posterior wall thickness and interventricular septum thickness)in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of cardiovascular events in the observation group was 4.44%(2/45),which was lower than 17.78%(8/45)in the control group,and the difference was statistically significant(χ^(2)=4.050,P=0.044).Conclusion When treating acute ST segment elevated myocardial infarction with percutaneous coronary intervention,the addition of tirofiban can enhance cardiac function,improve postoperative reperfusion,and reduce the incidence of adverse cardiovascular events,thereby providing protective benefits to the patients'physical and mental health.

关 键 词：替罗非班 经皮冠脉介入术 急性ST段抬高型心肌梗死 心脏功能 

分 类 号：R54[医药卫生—心血管疾病]