哌拉西林钠舒巴坦钠对慢性阻塞性肺疾病合并下呼吸道感染患者症状改善效果  

Effect of Piperacillin-sulbactam on Symptom Improvement in Patients with Chronic Obstructive Pulmonary Disease Complicated by Lower Respiratory Tract Infections

作　　者：吴佳玲 许蓉 杨柯 WU Jialing;XU Rong;YANG Ke(Department of Respiratory and Critical Care,Guihang Guiyang Hospital,Guiyang,Guizhou,550006,China)

机构地区：[1]贵航贵阳医院呼吸与危重症科,贵州贵阳550006

出　　处：《中外医疗》2025年第8期78-81,共4页China & Foreign Medical Treatment

摘　　要：目的探讨哌拉西林钠舒巴坦钠对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并下呼吸道感染患者症状的改善作用。方法随机选取2021年1月—2022年12月贵航贵阳医院收治的70例合并下呼吸道感染的COPD患者为研究对象,依据不同治疗方法分成两组,各35例。在基础治疗上,对照组使用左氧氟沙星进行治疗,观察组应用哌拉西林钠舒巴坦钠进行治疗。对比两组主要体征/症状消失时间、动脉血气指标、炎症因子水平、治疗效果与不良反应发生率。结果观察组患者咳嗽消失时间、咳痰消失时间、肺部啰音消失时间均短于对照组,差异均有统计学意义(P均<0.05)。治疗后,两组患者的动脉血氧分压指标水平、C反应蛋白、降钙素原水平优于治疗前,且观察组的氧分压、血氧饱和度高于对照组,二氧化碳分压、C反应蛋白、降钙素原水平低于对照组,差异均有统计学意义(P均<0.05)。治疗总有效率比较,对照组为77.14%(27/35),低于观察组的97.14%(34/35),差异有统计学意义(χ^(2)=4.590,P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论哌拉西林钠舒巴坦钠治疗COPD合并下呼吸道感染能改善患者咳嗽、咳痰等症状,改善血气状态,减轻炎症反应,且安全性高。Objective To explore the improvement effect of piperacillin-sulbactam on the symptoms of patients with chronic obstructive pulmonary disease(COPD)complicated by lower respiratory tract infections.Methods Seventy patients with COPD complicated by lower respiratory tract infections who were admitted to Guihang Guiyang Hospital from January 2021 to December 2022 were randomly selected as the research objects and divided into two groups according to different treatment methods,with 35 cases in each group.On the basis of basic treatment,the control group was treated with levofloxacin,while the observation group was treated with piperacillin-sulbactam.The disappearance time of main signs/symptoms,arterial blood gas indexes,levels of inflammatory factors,treatment efficacy and incidence of adverse reactions were compared between the two groups.Results The disappearance time of cough,expectoration and pulmonary rales in the observation group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of arterial partial pressure of oxygen,C-reactive protein(CRP),and procalcitonin(PCT)in both groups of patients were superior to those before treatment,the partial pressure of oxygen and oxygen saturation in the observation group were higher than those in the control group,while the partial pressure of carbon dioxide,and the levels of CRP and PCT were lower than those in the control group,and all the differences were statistically significant(all P<0.05).In terms of the comparison of the total treatment effective rate,the control group was 77.14%(27/35),which was lower than that of the observation group at 97.14%(34/35),and the difference was statistically significant(χ^(2)=4.590,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Piperacillin-sulbactam in the treatment of COPD complicated by lower respiratory tract infections can improve symptoms such as cough and

关 键 词：慢性阻塞性肺疾病 下呼吸道感染 哌拉西林舒巴坦 症状改善 

分 类 号：R563.1[医药卫生—呼吸系统]