腹腔镜手术患者应用右美托咪啶联合七氟烷方案的麻醉效果评估  

Evaluation of the Anesthetic Effect of Dexmedetomidine Combined with Sevoflurane in Laparoscopic Surgery Patients

作　　者：周森 李峰 钱宁 ZHOU Sen;LI Feng;QIAN Ning(Yangzhou University Affiliated Taizhou Second People's Hospital,Taizhou,Jiangsu,225500,China)

机构地区：[1]扬州大学附属泰州市第二人民医院,江苏泰州225500

出　　处：《中外医疗》2025年第8期82-85,共4页China & Foreign Medical Treatment

摘　　要：目的探讨右美托咪定与七氟烷联合方案对腹腔镜手术患者麻醉效果的影响。方法在2022年1月—2023年12月期间,随机选取实施腹腔镜手术治疗的患者150例,均为扬州大学附属泰州市第二人民医院收治,分组方式根据麻醉方案,分为对照组(75例)与观察组(75例)。对照组单独应用七氟烷,观察组联合应用七氟烷和右美托咪定,比较两组麻醉效果、血流动力学指标水平、血清学指标、认知功能、麻醉并发症发生率。结果相较于对照组的(15.15±3.10)min、(8.33±1.65)min、(18.03±2.92)min,观察组苏醒时间(10.44±1.36)min、自主呼吸恢复时间(5.28±0.71)min、定向力恢复时间(13.46±1.55)min均更短,差异均有统计学意义(t=12.049,14.704,11.971;P均<0.05)。术前,两组患者的血流动力学指标(收缩压、舒张压、心率)与血清学指标(去甲肾上腺素、肾上腺素、皮质醇)比较,差异均无统计学意义(P均>0.05);相较于对照组,麻醉后5 min、麻醉后30 min,观察组的血流动力学指标及血清学指标变化幅度更小,差异均有统计学意义(P均<0.05)。术前,两组患者的认知功能比较,差异无统计学意义(P>0.05);相较于对照组,苏醒后2 h,观察组患者认知功能评分更高,差异有统计学意义(P<0.05)。两组麻醉并发症发生率对比,差异无统计学意义(P>0.05)。结论右美托咪定联合七氟烷方案有助于提升腹腔镜手术患者的麻醉效果,对血流动力学指标、血清学指标及认知功能影响小,且安全性良好。Objective To explore the impact of the combined regimen of dexmedetomidine and sevoflurane on the anesthetic effect in patients undergoing laparoscopic surgery.Methods From January 2022 to December 2023,150 patients who underwent laparoscopic surgery were randomly selected and admitted to the Yangzhou University Affiliated Taizhou Second People's Hospital.The grouping method was based on the anesthesia plan,and they were divided into a control group(75 cases)and an observation group(75 cases).The control group was administered sevoflurane alone,while the observation group was given the combination of sevoflurane and dexmedetomidine.Anesthetic effects,hemodynamic indicators level,serum indicators level,cognitive function,and the incidence of anesthesia complications were compared between the two groups.Results Compared with the control group's(15.15±3.10)min,(8.33±1.65)min,and(18.03±2.92)min,the observation group had shorter awakening time(10.44±1.36)min,spontaneous breathing recovery time(5.28±0.71)min,and orientation recovery time(13.46±1.55)min,and the differences were statistically significant(t=12.049,14.704,11.971;all P<0.05).Before surgery,there were no statistically significant differences in the hemodynamic indicators(systolic blood pressure,diastolic blood pressure,heart rate)and serum indicators(norepinephrine,epinephrine,cortisol)between the two groups(all P>0.05);compared to the control group,the observation group showed smaller changes in hemodynamic and serological indicators at 5 and 30 minutes after anesthesia,and the differences were statistically significant(all P<0.05).Before surgery,there was no statistically significant difference in cognitive function between the two groups(P>0.05).Compared to the control group,the observation group had higher cognitive function scores 2 hours after awakening,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of anesthesia complications between the two groups(P>0.05).Conclusion Th

关 键 词：七氟烷 右美托咪定 腹腔镜手术 麻醉效果 认知功能 

分 类 号：R614[医药卫生—麻醉学]