肾小球滤过率、多配体蛋白聚糖1和不对称二甲基精氨酸联合诊断在2型糖尿病肾病早期诊断中的应用  

Application of Combined Diagnosis of Glomerular Filtration Rate,Syndecan-1 and Asymmetric Dimethylarginine in the Early Diagnosis of Type 2 Diabetic Nephropathy

作　　者：夏利明[1] 唐晓莹[2] 姚庆完[1] XIA Liming;TANG Xiaoying;YAO Qingwan(Department of Laboratory,Kunshan Center for Disease Control and Prevention,Kunshan 215300,Jiangsu,China;Department of Laboratory,Kunshan Third People's Hospital,Kunshan 215300,Jiangsu,China)

机构地区：[1]昆山市疾病预防控制中心检验科,江苏昆山215300 [2]昆山市第三人民医院检验科,江苏昆山215300

出　　处：《糖尿病新世界》2025年第5期52-55,共4页Diabetes New World

摘　　要：目的分析2型糖尿病肾病早期诊断中应用肾小球滤过率、多配体蛋白聚糖1(syndecan-1,SDC1)和不对称二甲基精氨酸(asymmetric dimethylarginine,ADMA)联合诊断效果。方法回顾性选取2022年11月—2024年8月昆山市第三人民医院收治的80例行糖尿病肾病早期诊断的糖尿病患者的临床资料,以24 h尿蛋白定量检测为金标准,检出35例为糖尿病肾病,45例为糖尿病。均进行肾小球滤过率、SDC1和ADMA检测,分析上述指标在该疾病中诊断效能,并比较各指标水平在两组患者中的差异。结果联合诊断灵敏度、特异度及准确度均高于单一检测,差异均有统计学意义(P均<0.05)。阳性组患者SDC1和ADMA水平均高于阴性组,而肾小球滤过率低于阴性组患者,差异均有统计学意义(P均<0.05)。结论在糖尿病肾病早期诊断领域中,单一指标临床检验具有一定局限性,指标联合诊断可显著提高诊断效能。Objective To analyze the combined diagnostic effects of glomerular filtration rate,syndecan-1(SDC1)and asymmetric dimethylarginine(ADMA)in the early diagnosis of type 2 diabetic nephropathy.Methods The clinical data of 80 diabetic patients with early diagnosis of diabetic nephropathy admitted to Kunshan Third People's Hospital from November 2022 to August 2024 were retrospectively selected.With 24-hour urine protein quantitative detection as the gold standard,35 cases were detected to be diabetic nephropathy and 45 cases were diabetes.Glomerular filtration rate,SDC1 and ADMA were detected.The diagnostic efficacy of the above indexes in the disease was analyzed,and the differences of each index level between the two groups were compared.Results The sensitivity,specificity and accuracy of combined diagnosis were higher than those of single detection,and the differences were statistically significant(all P<0.05).The levels of SDC1 and ADMA in of positive group were higher than those in patients of negative group,while the glomerular filtration rate was lower than that in patients of negative group,and the differences were statistically significant(all P<0.05).Conclusion In the field of early diagnosis of diabetic nephropathy,the clinical test of single index has certain limitations,and the combined diagnosis of indexes can significantly improve the diagnostic efficiency.

关 键 词：2型糖尿病肾病 肾小球滤过率 诊断效能 

分 类 号：R580[医药卫生—内分泌] R587.2[医药卫生—内科学]