糖尿病合并急性脑梗死患者经阿司匹林、氯吡格雷治疗的预后价值分析  

Analysis of the Prognostic Value of Aspirin and Clopidogrel in Patients with Diabetes Mellitus Complicated with Acute Cerebral Infarction

作　　者：赵锡吉 王哲 曹娟 耿贝贤 ZHAO Xiji;WANG Zhe;CAO Juan;GENG Beixian(Department of Internal Medicine,Zibo Occupational Disease Prevention and Control Hospital(Zibo Sixth People's Hospital),Zibo 255000,Shandong,China;Department of Cardiology,Zibo Occupational Disease Prevention and Control Hospital(Zibo Sixth People's Hospital),Zibo 255000,Shandong,China;Department of Rehabilitation Medi-cine,Zibo Occupational Disease Prevention and Control Hospital(Zibo Sixth People's Hospital),Zibo 255000,Shan-dong,China)

机构地区：[1]淄博市职业病防治院(淄博市第六人民医院)内科,山东淄博255000 [2]淄博市职业病防治院(淄博市第六人民医院)心内科,山东淄博255000 [3]淄博市职业病防治院(淄博市第六人民医院)康复医学科,山东淄博255000

出　　处：《糖尿病新世界》2025年第5期103-106,共4页Diabetes New World

摘　　要：目的分析糖尿病合并急性脑梗死患者经阿司匹林、氯吡格雷治疗的预后价值。方法选取2020年1月—2022年9月淄博市职业病防治院(淄博市第六人民医院)收治的糖尿病合并急性脑梗死患者70例,根据用药方案分组,对照组(n=35)服用阿司匹林,观察组(n=35)服用阿司匹林与氯吡格雷。比较两组血糖指标、血清细胞因子与神经功能。结果用药后,两组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白水平相较用药前均下降,差异均有统计学意义(P均<0.05);两组血糖指标比较,差异均无统计学意义(P均>0.05)。用药后,观察组血管内皮生长因子含量更高,而同型半胱氨酸、金属蛋白酶-9水平以及美国国立卫生研究院卒中量表评分更低,差异均有统计学意义(P均<0.05)。结论阿司匹林、氯吡格雷的协同应用可发挥更理想的调控血清细胞因子的能效,通过保护患者神经系统,缓解高血糖的不良影响,促进脑梗死病症转归。Objective To analyze the prognostic value of aspirin and clopidogrel in patients with diabetes mellitus complicated with acute cerebral infarction.Methods A total of 70 patients with diabetes mellitus complicated with acute cerebral infarction admitted to Zibo Occupational Disease Prevention and Control Hospital(Zibo Sixth People's Hospital)from January 2020 to September 2022 were selected and grouped according to the medication regimen.The control group(n=35)took aspirin,and the observation group(n=35)took aspirin and clopidogrel.Blood glucose indexes,serum cytokines and neurological function were compared between the two groups.Results After treatment,the levels of fasting blood glucose,2-hour postprandial blood glucose and glycated hemoglobin A1c in the two groups were lower than those before treatment,and the differences were statistically significant(all P<0.05).There were no significant differences in blood glucose indexes between the two groups(all P>0.05).The content of vascular endothelial growth factor in the observation group was higher,while the levels of homocysteine,matrix metalloproteinase-9 and National Institute of Health Stroke Scale score were lower,and the differences were statistically significant(all P<0.05).Conclusion The synergistic application of aspirin and clopidogrel can play a more ideal role in regulating the efficiency of serum cytokines.By protecting the nervous system of patients,it can alleviate the adverse effects of hyperglycemia and promote the outcome of cerebral infarction.

关 键 词：糖尿病 急性脑梗死 血糖 血清细胞因子 神经功能 

分 类 号：R58[医药卫生—内分泌]