甘精胰岛素结合阿卡波糖治疗2型糖尿病对血糖及安全性的影响  

Effect of Insulin Glargine Combined with Acarbose on Blood Glucose and Safety in the Treatment of Type 2 Diabetes Mellitus

作　　者：许言诺 袁雪璐 蒋莹 XU Yannuo;YUAN Xuelu;JIANG Ying(Department of Endocrinology and Oncology,Yixing Second People's Hospital(Yixing Occupational Disease Prevention Hospital),Yixing 214221,Jiangsu,China)

机构地区：[1]宜兴市第二人民医院(宜兴市职业病防治院)内分泌肿瘤科,江苏宜兴214221

出　　处：《糖尿病新世界》2025年第5期110-113,共4页Diabetes New World

摘　　要：目的探究2型糖尿病(type 2 diabetes mellitus,T2DM)患者实施甘精胰岛素联合阿卡波糖治疗方案的效果。方法根据治疗方法不同,将2021年1月—2024年9月宜兴市第二人民医院收治的120例T2DM患者分为研究组、对照组。对照组(60例)给予甘精胰岛素治疗,研究组(60例)在对照组的基础上加用阿卡波糖治疗。比较两组血糖控制情况、胰岛功能指标、不良反应发生率。结果研究组治疗后的空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹胰岛素、胰岛β细胞功能指数、胰岛素抵抗指数均更优,差异均有统计学意义(P均<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论甘精胰岛素联合阿卡波糖治疗能够改善T2DM患者的血糖控制情况,提高胰岛功能,且安全性较好。Objective To explore the effect of insulin glargine combined with acarbose in patients with type 2 diabetes mellitus(T2DM).Methods A total of 120 patients with T2DM admitted to Yixing Second People's Hospital from January 2021 to September 2024 were divided into study group and control group according to different treatment methods.The control group(60 cases)was treated with insulin glargine,and the study group(60 cases)was treated with acarbose on the basis of the control group.The blood glucose control,islet function indexes and incidence of adverse reactions were compared between the two groups.Results The fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglobin A1c,fasting insulin,homeostasis model assessment-βand homeostasis model assessmentinsulin resistance in the study group were better,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions between the two groups showed no significant difference(P>0.05).Conclusion Insulin glargine combined with acarbose can improve blood glucose control and islet function in patients with T2DM,and has good safety.

关 键 词：甘精胰岛素 阿卡波糖 2型糖尿病 血糖控制 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌]