抗反转录病毒治疗时长对人类免疫缺陷病毒/获得性免疫缺陷综合征患者机体代谢水平的影响  

The Impact of the Duration of Antiretroviral Therapy on the Body Metabolism of HIV/AIDS Patients

作　　者：吴宣达 李骞[2] 刘江福[3] WU Xuanda;LI Qian;LIU Jiangfu(Department of General Practic,Quanzhou city Licheng District Jiangnan Street Community Health Service Center,Quanzhou,Fujian 362000,China;Department of General Practice,The First Hospital of Quanzhou Affiliated to Fujian Medical University,Quanzhou,Fujian 362000,China;Department of Infectious Diseases,The First Hospital of Quanzhou Affiliated to Fujian Medical University,Quanzhou,Fujian 362000,China)

机构地区：[1]泉州市鲤城区江南街道社区卫生服务中心全科医学科,福建泉州362000 [2]福建医科大学附属泉州第一医院全科医学科,福建泉州362000 [3]福建医科大学附属泉州第一医院感染病科,福建泉州362000

出　　处：《中国医药指南》2025年第11期56-58,共3页Guide of China Medicine

摘　　要：目的探讨抗逆转录病毒(ART)治疗时长对人类免疫缺陷病毒/获得性免疫缺陷综合征(HIV/AIDS)患者机体代谢的影响。方法选取泉州市鲤城区江南街道社区卫生服务中心2021年9月至2024年2月90例接受ART治疗的HIV/AIDS患者,根据治疗时长分为:A组(0.5~2年)、B组(2~5年,含2年)和C组(≥5年)。对比分析3组血脂代谢、血糖代谢、肝肾功能情况。结果A组高胆固醇血症的发生率为10.00%,B组为16.67%,C组为23.33%,差异有统计学意义(P<0.05)。3组的高胆固醇症、甘油三酯血症、高低密度脂蛋白血症、低高密度脂蛋白血症、估算肾小球滤过率异常、低磷血症、高尿酸血症、糖尿病及丙氨酸氨基转移酶>50 U/L的发生率差异均无统计学意义(P>0.05)。结论ART治疗超过半年的HIV/AIDS患者常出现血脂异常,且会影响肝功能,治疗中应做好相关监测。Objective To investigate the effects of antiretroviral therapy(ART)treatment duration on metabolism of patients with HIV/AIDS.Methods A total of 90 patients with HIV/AIDS patients who received ART treatment from Quanzhou city Licheng district Jiangnan street community health service center from September 2021 to February 2024 were selected and divided into group A(0.5-2 years),Group B(2-5 years,including 2 years)and group C(≥5 years)according to the treatment duration.The blood lipid,blood glucose metabolism,liver and kidney function of the three groups were compared and analyzed.Results Through detection and analysis,the incidence of hypercholesterolemia(TC)in group A was 10.0%,16.67%in group B,and 23.33%in group C.The difference between the groups was statistically significant(P<0.05).There were no significant differences in the incidences of hypertriglyceridemia(TG),high low-density lipoprotein cholesterol(LDL)-emia,low high-density lipoprotein cholesterol(HDL)-emia,abnormal estimated glomerular filtration rate(eGFR),hypophosphatemia,hyperuricemia,diabetes,and alanine aminotransferase(ALT)>50 U/L among the three groups(P>0.05).Conclusions HIV/AIDS patients treated with ART for more than half a year often have dyslipidemia,which will affect liver function,and relevant monitoring should be done during treatment.

关 键 词：获得性免疫缺陷综合征 抗反转录病毒 治疗时长 人类免疫缺陷病毒 代谢异常 

分 类 号：R512.91[医药卫生—内科学]