达格列净与利格列汀对双胍类/磺脲类控制不佳的社区2型糖尿病患者血糖及脂代谢的影响对比  

Comparison of the Effects of Daggliptin and Liggliptin on Blood Glucose Fluctuation and Lipid Metabolism in Community Type 2 Diabetes Patients with Poorly Controlled Biguanides/Sulfonylureas

作　　者：郑秋平 曾振华 林碧华 黄瑞程 ZHENG Qiuping;ZENG Zhenhua;LIN Bihua;HUANG Ruicheng(Department of General Practice Medicine,Donghu Street Community Health Service Center,Fengze District,Quanzhou,Fujian 362000,China;Department of Hematology and Oncology,Wuping County Hospital,Longyan,Fujian 364300,China;Department of Nursing,Wuping County Maternal and Child Health Hospital,Longyan,Fujian 364300,China;Department of Pharmacy,Donghu Street Community Health Service Center,Quanzhou,Fujian 362000,China)

机构地区：[1]泉州市丰泽区东湖街道社区卫生服务中心全科医学科,福建泉州362000 [2]武平县医院血液肿瘤科,福建龙岩364300 [3]武平县妇幼保健院护理科,福建龙岩364300 [4]泉州市丰泽区东湖街道社区卫生服务中心药房,福建泉州362000

出　　处：《中国医药指南》2025年第11期81-83,共3页Guide of China Medicine

摘　　要：目的比较达格列净与利格列汀对双胍类/磺脲类控制不佳的社区2型糖尿病(T2DM)患者的影响。方法选取2022年3月至2024年3月福建省泉州市丰泽区东湖街道社区卫生服务中心收治的T2DM患者80例,以随机数字表法分为对照组(予以利格列汀,40例)和观察组(予以达格列净,40例)。统计体重指数、血糖指标、脂代谢、炎症指标、不良反应。结果治疗后,观察组体重指数、糖化血红蛋白(HbAlc)、2 h血糖(2 h PG)、空腹血糖(FPG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇、三酰甘油、C反应蛋白(CRP)水平均低于对照组,高密度脂蛋白胆固醇(HDL-C)均高于对照组(P<0.05)。观察组与对照组在不良反应发生情况上对比,差异无统计学意义(P>0.05)。结论达格列净可促进患者血糖水平改善,加快脂代谢水平、炎症水平恢复,且不会增加药物不良反应。Objective To compare the effects of daggliptin and liggliptin on type 2 diabetes(T2DM)patients in community with poorly controlled biguanides/sulfonylureas.Methods A total of 80 T2DM patients admitted to Donghu Street Community Health Service Center in Fengze District,Quanzhou City,Fujian Province from March 2022 to March 2024 were randomly divided into two groups using a random number table.The control group(40 cases)was treated with sitagliptin,while the observation group(40 cases)was treated with dapagliflozin.Statistical analysis of body mass index,blood glucose indicators,lipid metabolism,inflammation indicators,and adverse reactions.Results After treatment,the body mass index,glycated hemoglobin(HbAlc),2-hour blood glucose(2 h PG),fasting blood glucose(FPG),low-density lipoprotein cholesterol(LDL-C),total cholesterol,triglycerides(TG),and C-reactive protein(CRP)levels in the observation group were all lower than those in the control group.The scores of high-density lipoprotein cholesterol(HDL-C)were higher than those in the control group,with statistical differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusions In community T2DM patients with poorly controlled biguanides/sulfonylureas,dagaglipzin can promote the improvement of blood glucose levels,accelerate the recovery of lipid metabolism and inflammation levels,and does not increase adverse drug reactions.

关 键 词：2型糖尿病 双胍类/磺脲类控制不佳 利格列汀 达格列净 脂代谢 血糖 

分 类 号：R587.1[医药卫生—内分泌]