血清PGC-1α、铁蛋白及腰椎骨密度、股骨颈强度指数与髋部骨折术后骨愈合、关节功能的关联性  

Correlation between serum PGC-1α,ferritin,lumbar spine bone density,femoral neck strength index and postoperative bone healing and joint function in hip fractures

作　　者：陶简 陆志前 修智 TAO Jian;LU Zhi-qian;XIU Zhi(Department of Imaging,Xuancheng People's Hospital,Xuancheng Anhui 242000,China)

机构地区：[1]宣城市人民医院影像科,安徽宣城242000

出　　处：《临床和实验医学杂志》2025年第5期486-490,共5页Journal of Clinical and Experimental Medicine

基　　金：安徽省社会科学创新发展研究课题(编号:2021CX186)。

摘　　要：目的探讨血清过氧化物酶体增殖物激活受体γ共激活因子-1α(PGC-1α)、铁蛋白、腰椎骨密度、股骨颈强度指数(FSI)与髋部骨折术后骨愈合、关节功能的关系。方法前瞻性选取2022年1月至2024年9月在宣城市人民医院治疗的髋部骨折患者160例作为研究对象。根据骨折愈合情况,将患者分为骨折愈合良好组(n=128)和骨折愈合不良组(n=32);根据髋关节功能恢复情况,将患者分为髋关节功能恢复良好组(n=98)和髋关节功能恢复不良组(n=62)。收集患者的临床资料,包括性别、年龄、骨折部位、手术方式、手术时间、骨折节段、基础疾病史、术后关节康复训练情况等。分析骨折愈合良好组和骨折愈合不良组、髋关节功能恢复良好组和髋关节功能恢复不良组患者临床资料、PGC-1α、铁蛋白、腰椎骨密度、FSI的差异;采用多因素Logistic回归模型分析影响骨折愈合、髋关节功能恢复的因素;采用受试者操作特征(ROC)曲线分析铁蛋白、PGC-1α预测骨折愈合、髋关节功能恢复的价值。结果骨折愈合不良组患者年龄、糖尿病占比、铁蛋白分别为(78.89±8.22)岁、53.13%和(215.54±36.68)ng/mL,均明显高于骨折愈合良好组患者[(72.21±6.22)岁、29.69%和(145.58±27.54)ng/mL],而骨折愈合不良组患者PGC-1α和腰椎骨密度分别为(1.98±0.81)pg/mL和(0.78±0.26)g/cm^(2),均明显低于骨折愈合良好组患者[(3.11±0.95)pg/mL和(0.95±0.21)g/cm^(2)],差异均有统计学意义(P<0.05)。髋关节功能恢复不良组患者年龄、糖尿病占比、铁蛋白分别为(76.68±8.10)岁、46.77%和(188.65±30.41)ng/mL,均明显高于髋关节功能恢复良好组患者[(71.56±8.03)岁、16.33%和(141.18±32.50)ng/mL],而髋关节功能恢复不良组患者术后关节康复训练占比、PGC-1α和FSI分别为45.16%、(2.03±0.88)pg/mL和0.83±0.30,均明显低于髋关节功能恢复良好组患者[75.51%、(3.42±0.96)pg/mL和1.10±0.29],差异均有统计学Objective To explore the relationship between serum peroxisome proliferator activated receptorγco activator factor-1α(PGC-1α),serum ferritin,lumbar spine bone density,femoral neck strength index,and postoperative bone healing and joint function in hip fractures.Methods A total of 160 patients with hip fracture treated in Xuancheng People's Hospital from January 2022 to September 2024 were prospectively selected as the study subjects.According to the condition of fracture healing,the patients were divided into the good fracture healing group(n=128)and the poor fracture healing group(n=32).According to the recovery of hip joint function,the patients were divided into the good hip joint function recovery group(n=98)and the poor hip joint function recovery group(n=62).The clinical data of the patients were collected,including gender,age,fracture site,operation method,operation time,fracture segment,basic disease history,postoperative joint rehabilitation training and so on.The differences of clinical data,PGC-1α,ferritin,lumbar bone density and FSI between the good fracture healing group and the poor fracture healing group,the good hip joint function recovery group and the poor hip joint function recovery group were analyzed.The factors affecting fracture healing and hip joint function recovery was analyzed using multivariate Logistic regression model.The value of ferritin and PGC-1αin predicting fracture healing and hip joint function recovery was analyzed by receiver operating characteristic(ROC)curve.Results The age,proportion of diabetes and ferritin of the poor fracture healing group were(78.89±8.22)years,53.13%and(215.54±36.68)ng/mL,respectively,which were significantly higher than those of the good fracture healing group[(72.21±6.22)years,29.69%and(145.58±27.54)ng/mL],while PGC-1αand the bone mineral density of lumbar spine of the poor fracture healing group were(1.98±0.81)pg/mL and(0.78±0.26)g/cm^(2),respectively,which were significantly lower than those of the good fracture healing group[(3.11±0

关 键 词：过氧化物酶体增殖物激活受体γ共激活因子-1α 铁蛋白 腰椎骨密度 股骨颈强度指数 髋部骨折 骨愈合 关节功能 

分 类 号：R687.3[医药卫生—骨科学]