新诊断2型糖尿病患者β细胞第一时相分泌功能与颈部动脉粥样硬化斑块的相关性研究  

Correlation between β cell first time phase secretion function and carotid atherosclerotic plaques in newly diagnosed type 2 diabetes mellitus patients

作　　者：王晓明[1] 张洋 王鲲[1] 田伊茗[1] 刘鑫[1] 王锐[1] WANG Xiao-ming;ZHANG Yang;WANG Kun(Department of Endocrinology,The First Hospital of Qinhuangdao,Qinhuangdao Hebei 066000,China;Department of Thoracic Surgery,Fengfeng General Hospital,North China Medical and Health Group,Handan Hebei 056200,China)

机构地区：[1]秦皇岛市第一医院内分泌科,河北秦皇岛066000 [2]华北医疗健康集团峰峰总医院甲乳外科,河北邯郸056200

出　　处：《临床和实验医学杂志》2025年第6期605-609,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省卫生健康委科研基金项目(编号:20240384)。

摘　　要：目的探究新诊断2型糖尿病(T2DM)患者β细胞第一时相分泌功能与颈部动脉粥样硬化斑块的相关性。方法前瞻性选取2022年9月至2024年8月秦皇岛市第一医院收治的新诊断的T2DM患者70例及同期健康体检者60名作为研究对象,分别作为病例组和对照组。统计并比较两组受检者的一般资料(性别、年龄、体重指数、疾病史、吸烟、饮酒、收缩压、舒张压)、实验室指标[甘油三酯、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、同型半胱氨酸(Hcy)、空腹血糖、糖化血红蛋白(GHb)、尿酸]、颈部动脉粥样硬化斑块检出情况及急性胰岛素反应(AIR 3~5)。利用Pearson相关分析AIR 3-5与各变量的相关性;采用多元逐步回归分析探究β细胞第一时相分泌功能的影响因素。结果两组受检者在性别构成比、年龄、疾病史(高血压、冠心病)、吸烟、饮酒、收缩压、舒张压、总胆固醇、LDL-C、HDL-C和Hcy方面比较,差异均无统计学意义(P>0.05);病例组患者体重指数、甘油三酯、空腹血糖、GHb、尿酸分别为(28.62±4.23)kg/m^(2)、(2.87±0.56)mmol/L、(7.73±0.36)mmol/L、(8.36±0.52)%、(420.25±89.55)μmol/L,均明显高于对照组[(25.48±3.66)kg/m^(2)、(1.68±0.46)mmol/L、(5.26±0.63)mmol/L、(5.62±0.67)%、(340.26±42.54)μmol/L],差异均有统计学意义(P<0.05)。病例组患者颈部斑块检出率为64.29%,显著高于对照组,且AIR 3-5水平为(4.25±0.80)μU/mL,显著低于对照组[(7.64±1.45)μU/mL],差异均有统计学意义(P<0.05)。体重指数、甘油三酯、空腹血糖、GHb、尿酸、颈部斑块检出率与AIR 3-5均呈负相关(P<0.05)。多元逐步回归分析结果表明,体重指数、甘油三酯、颈部斑块是AIR 3-5的影响因素(P<0.05)。结论新诊断T2DM患者β细胞第一时相分泌功能与颈部动脉粥样硬化斑块的形成存在显著相关性。患者体重指数、甘油三酯水平以及颈部斑块检出情况是�Objective To investigate the correlation between β cell first time phase secretion function and carotid atherosclerotic plaque in newly diagnosed type 2 diabetes mellitus(T2DM)patients.Methods A prospective study was conducted from September 2022 to August 2024,involving 70 newly diagnosed T2DM patients admitted to the First Hospital of Qinhuangdao and 60 healthy individuals.The study subjects were designated as the case group and the control group,respectively.The general information(gender,age,body mass index,history of disease,smoking,drinking,systolic blood pressure,diastolic blood pressure),laboratory indicators[triglyceride,total cholesterol,low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),homocysteine(Hcy),fasting blood glucose,glycosylated hemoglobin(GHb),uric acid]and the detection of cervical atherosclerotic plaque were analyzed.The correlation between AIR 3-5 and each variable was analyzed using Pearson correlation analysis.The influencing factors of the first phase secretion function ofβcells was explored using Multiple stepwise regression analysis.Results There were no significant differences in gender composition ratio,age,disease history,smoking,drinking,systolic blood pressure,diastolic blood pressure,total cholesterol,LDL-C,HDL-C and Hcy between the two groups(P>0.05).The levels of body mass index,triglyceride,fasting blood glucose,GHb and uric acid in the case group were(28.62±4.23)kg/m^(2),(2.87±0.56)mmol/L,(7.73±0.36)mmol/L,(8.36±0.52)%and(420.25±89.55)μmol/L,respectively,which were significantly higher than those in the control group[(25.48±3.66)kg/m^(2),(1.68±0.46)mmol/L,(5.26±0.63)mmol/L,(5.62±0.67)% and(340.26±42.54)μmol/L],and the differences were statistically significant(P<0.05).The cervical plaque detection rate of the case group was 64.29%,which was significantly higher than that of the control group(25.00),and the AIR 3-5 was(4.25±0.80)μU/mL,which was significantly lower than that of the control group(7.64±1.45)μU/mL,and the dif

关 键 词：新诊断2型糖尿病 β细胞第一时相分泌功能 颈部动脉粥样硬化斑块 相关性 

分 类 号：R587.1[医药卫生—内分泌]