血清CTRP3、趋化素及内脂素水平与妊娠期糖尿病患者糖脂代谢相关性及对不良妊娠结局的预测价值  

Correlation between serum CTRP3,chemokine and lactone levels and glycolipid metabolism in patients with gestational diabetes mellitus and their predictive value for adverse pregnancy outcomes

作　　者：王同娜 董智力[1] 渠爱华 高瑞雪 WANG Tong-na;DONG Zhi-li;QU Ai-hua(Department of Obstetrics and Gynecology,The Second People's Hospital of Hengshui,Hengshui Hebei 053000,China)

机构地区：[1]衡水市第二人民医院妇产科,河北衡水053000

出　　处：《临床和实验医学杂志》2025年第6期613-617,共5页Journal of Clinical and Experimental Medicine

基　　金：河北省科学技术厅项目(编号:20200678);衡水市科学技术局计划项目(编号:11037A)。

摘　　要：目的分析血清脂肪细胞因子C1q/肿瘤坏死因子相关蛋白3(CTRP3)、趋化素及内脂素水平与妊娠期糖尿病(GDM)患者糖脂代谢相关性及对不良妊娠结局的预测价值。方法回顾性选取2022年1月至2024年6月在衡水市第二人民医院被确诊且接受治疗的GDM患者资料,纳入不良妊娠结局的36例患者为不良组,另从妊娠结局良好的患者中选取72例纳入良好组。比较两组患者血糖[空腹血糖(FBG)、糖化血红蛋白(GHb)]、血脂指标[甘油三酯、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、血清CTRP3、趋化素及内脂素水平;采用Logistic分析血清CTRP3、趋化素及内脂素水平与GDM患者不良妊娠结局的关系;采用受试者操作特征(ROC)曲线分析血清CTRP3、趋化素及内脂素水平及3项指标联合应用对GDM患者不良妊娠结局的预测价值;采用Pearson相关性分析探讨血清CTRP3、趋化素及内脂素水平与糖脂代谢指标的相关性。结果不良组患者FBG、GHb、甘油三酯分别为(11.79±2.17)mmol/L、(12.06±2.15)%、(2.22±0.42)mmol/L,均高于良好组[(8.95±1.11)mmol/L、(9.12±1.04)%、(1.93±0.33)mmol/L],差异均有统计学意义(P<0.05);两组患者总胆固醇、HDL-C、LDL-C水平比较,差异均无统计学意义(P>0.05)。不良组患者血清CTRP3水平为(407.14±15.92)ng/L,低于良好组[(430.93±17.61)ng/L],趋化素、内脂素水平分别为(10.74±2.16)、(7.85±1.00)ng/mL,均高于良好组[(8.15±1.16)、(5.76±0.80)ng/mL],差异均有统计学意义(P<0.05)。血清CTRP3水平偏高为不良妊娠结局的保护因素(P<0.05),趋化素、内脂素水平偏高为不良妊娠结局的危险因素(P<0.05);血清CTRP3、趋化素、内脂素对于GDM患者不良妊娠结局均具有中等预测价值(P<0.05),3项血清指标联合应用对于GDM患者不良妊娠结局均具有较高预测价值(P<0.05)。CTRP3与FBG、GHb、甘油三酯均呈高度负相关(P<0.05),趋化素、内脂素与FBG、GObjective To analyze the correlation between serum adipocyte C1q tumor necrosis factor related protein-3(CTRP3),chemokine and lactone levels and glucose and lipid metabolism in patients with gestational diabetes mellitus(GDM)and their predictive value for adverse pregnancy outcomes.Methods The data of GDM patients diagnosed and treated in the Second People's Hospital of Hengshui from January 2022 to June 2024 were retrospectively selected.Thirty-six patients with adverse pregnancy outcomes were included in the adverse group,and 72 patients with good pregnancy outcomes were included in the good group.The levels of blood glucose[fasting blood glucose(FBG),glycosylated hemoglobin(GHb)],blood lipid indexes[triglyceride,total cholesterol,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)],serum CTRP3,chemerin and visfatin were compared between the two groups.The specific relationship between serum CTRP3,chemokine and lactone levels and adverse pregnancy outcomes in GDM patients was analyzed using Logistic analysis.The predictive value of serum CTRP3,chemokine and lactone levels and their combined application in adverse pregnancy outcomes in GDM patients was analyzed using receiver operating characteristic(ROC)curve.The correlation between serum CTRP3,chemokine and visfatin levels and glucose and lipid metabolism indexes in GDM patients was investigated using Pearson correlation analysis.Results The levels of FBG,GHb and triglyceride in the adverse group were(11.79±2.17)mmol/L,(12.06±2.15)%and(2.22±0.42)mmol/L,respectively,which were higher than those in the good group[(8.95±1.11)mmol/L,(9.12±1.04)%and(1.93±0.33)mmol/L],and the differences were statistically significant(P<0.05).There were no statistically significant differences in the levels of total cholesterol,HDL-C and LDL-C between the two groups(P>0.05).The serum CTRP3 level in the adverse group was(407.14±15.92)ng/L,which was lower than that in the good group[(430.93±17.61)ng/L,the levels of chemerin and visfatin were(

关 键 词：妊娠期糖尿病 脂肪细胞因子C1q/肿瘤坏死因子关蛋白3 趋化素 内脂素 糖脂代谢 不良妊娠结局 预测 

分 类 号：R714.256[医药卫生—妇产科学]