自拟柴郁胸痹汤治疗冠心病稳定型心绞痛的疗效及对心功能和运动耐力的影响  

Efficacy of self-prescribed Chaiyu Chest Impediment Decoction in treating stable angina pectoris in coronary heart disease and its impact on cardiac function and exercise tolerance

作　　者：陶亚丽 罗亚敏 周飞 TAO Ya-li;LUO Ya-min;ZHOU Fei(Department of CardiologyⅠ,Nanyang Nanshi Hospital,Nanyang 473000,Henan,CHINA)

机构地区：[1]南阳南石医院心内科一病区,河南南阳473000

出　　处：《海南医学》2025年第7期930-933,共4页Hainan Medical Journal

基　　金：2021年度河南省医学科技攻关计划联合共建项目(编号:LHGJ20210392)。

摘　　要：目的探讨自拟柴郁胸痹汤治疗冠心病稳定型心绞痛的疗效及对心功能、运动耐力的影响。方法选取2022年1月至2024年1月南阳南石医院收治的90例冠心病稳定型心绞痛患者作为研究对象,按随机数表法分为观察组和对照组各45例。对照组患者给予美托洛尔治疗,观察组患者在对照组治疗的基础上给予自拟柴郁胸痹汤治疗,两组患者均治疗1个月。治疗1个月后,比较两组患者的临床疗效,以及治疗前、治疗1个月后的心功能指标[左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)]、运动耐力指标[6 min步行距离(6MWT)、峰值通气率、峰值摄氧量],并记录两组患者治疗期间的不良反应发生情况。结果观察组患者治疗后的临床总有效率为95.56%,明显高于对照组的82.22%,差异有统计学意义(P<0.05)。治疗前,两组患者的LVEDD、LVESD及LVEF水平比较差异均无统计学意义(P>0.05);治疗后,观察组患者的LVEDD、LVESD水平分别为(50.43±3.18)mm、(45.41±2.05)mm,明显低于对照组的(56.90±4.20)mm、(50.23±2.52)mm,LVEF为(56.40±4.35)%,明显高于对照组的(50.03±3.91)%,差异均有统计学意义(P<0.05)。治疗前,两组患者的6 min步行距离、峰值通气率和峰值摄氧量水平比较差异均无统计学意义(P>0.05);治疗后,观察组患者的6 min步行距离、峰值通气率和峰值摄氧量水平分别为(406.34±21.57)m、(26.36±3.85)%、(20.32±2.05)mL/(kg·min),明显高于对照组的(367.68±20.36)m、(23.16±3.62)%、(18.42±1.94)m L/(kg·min),差异均有统计学意义(P<0.05)。观察组患者治疗期间的不良反应总发生率为11.11%,略高于对照组的8.89%,但差异无统计学意义(P>0.05)。结论自拟柴郁胸痹汤治疗冠心病稳定型心绞痛能改善患者的心功能,提高运动耐力,临床应用效果显著且安全性较高。Objective To investigate the efficacy of self-prescribed Chaiyu Chest Impediment Decoction in treating stable angina pectoris in coronary heart disease(CHD)and its impact on cardiac function and exercise tolerance.Methods A total of 90 patients with stable angina pectoris due to CHD admitted to Nanyang Nanshi Hospital from January 2022 to January 2024 were selected as the study subjects.They were divided into an observation group and a control group using a random number table,with 45 patients in each group.The control group was treated with metoprolol,while the observation group received the self-prescribed Chaiyu Chest Impediment Decoction in addition to the control group's treatment.Both groups were treated for one month.After one month of treatment,the clinical efficacy of the two groups was compared,along with cardiac function indicators and exercise tolerance indicators before and after treatment:left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)vs 6-minute walk distance(6MWT),peak ventilation rate,peak oxygen uptake.Adverse reactions during the treatment period were also recorded.Results The total clinical efficacy rate in the observation group after treatment was 95.56%,significantly higher than 82.22%in the control group(P<0.05).Before treatment,there were no significant differences in LVEDD,LVESD,or LVEF levels between the two groups(P>0.05).After treatment,the LVEDD and LVESD levels in the observation group were(50.43±3.18)mm and(45.41±2.05)mm,respectively,significantly lower than(56.90±4.20)mm and(50.23±2.52)mm in the control group.The LVEF in the observation group was(56.40±4.35)%,significantly higher than(50.03±3.91)%in the control group(P<0.05).Before treatment,there were no significant differences in 6-minute walk distance,peak ventilation rate,or peak oxygen uptake between the two groups(P>0.05).After treatment,the 6-minute walk distance,peak ventilation rate,and peak oxygen uptake in the observation group we

关 键 词：冠心病 稳定型心绞痛 柴郁胸痹汤 疗效 心功能 运动耐力 

分 类 号：R541.4[医药卫生—心血管疾病]