广谱抗菌药硝唑尼特的研究趋势  

Research Ends of the Broad-spectrum Antimicrobial Nitazoxanide

作　　者：周志强 丁义凯 Zhou Zhiqiang;Ding Yikai(Hangzhou Disheng Import and Export Co.,Ltd.,Hangzhou 310014,China)

机构地区：[1]杭州帝盛进出口有限公司,浙江杭州310014

出　　处：《广东化工》2025年第6期84-85,73,共3页Guangdong Chemical Industry

摘　　要：综述了硝唑尼特作为一种新型的广谱抗菌药物,经过40多年的合成和应用的研究,开发了多种合成路线,通过精制得到高纯度的原料药,现已得到了工业化生产应用,临床用于治疗肠道寄生虫类疾病和慢性乙肝疾病。文中介绍了各种合成工艺的优缺点,简述了药物的临床应用新的趋势和硝唑尼特的检测方法,拓展说明了硝唑尼特衍生物的开发和性能特点。Nitazonidite as a novel broad-spectrum antimicrobial,after more than 40 years of synthesis and application research,developed a variety of synthetic routes,through refining the high purity API,has been used in industrial production and application,clinical use for the treatment of intestinal parasites and chronic hepatitis B diseases.This paper introduces the advantages and disadvantages of various synthetic processes,briefly describes the new clinical trend of drugs and the detection method of nitzonite,and expands the development and performance characteristics of nitzonite derivatives.

关 键 词：硝唑尼特 合成技术 抗菌药 衍生物 

分 类 号：TQ[化学工程]