基于UHPLC-Q-TOF-MS技术快速分析桃核承气汤中的化学成分  

Rapid Analysis of Chemical Constituents in Taohe Chengqi Decoction based on UHPLC-Q-TOF-MS

作　　者：张维君 王宗权 李艳英 林雨芹 王瑞 潘悦 周毅生 曹晖[4] Zhang Weijun;Wang Zongquan;Li Yanying;Lin Yuqin;Wang Rui;Pan Yue;Zhou Yisheng;Cao Hui(Increase Pharm(Hengqin)Institute Co.,Ltd.,Zhuhai 519031,China;Beijing Increase Innovative Drug Co.,Ltd.,Beijing 102200,China;Chengdu Sensonvo Bio medicine Com.,Ltd.,Chengdu 610200,China;Jinan University,Guangzhou 510660,China)

机构地区：[1]盈科瑞(横琴)药物研究院有限公司,广东珠海519031 [2]北京盈科瑞创新医药股份有限公司,北京102200 [3]成都诺和晟欣生物医药有限公司,四川成都610200 [4]暨南大学,广东广州510660

出　　处：《广东化工》2025年第6期133-137,共5页Guangdong Chemical Industry

基　　金：广东省科技计划项目,课题名称《改善肿瘤免疫治疗敏感性创新药物的发现及临床前研究》(2022A0505020024)。

摘　　要：目的:应用UHPLC-Q-TOF-MS技术分析桃核承气汤中的化学成分。方法:运用UHPLC-Q-TOF-MS法,对桃核承气汤进行质谱扫描,参考文献及对照品,对其进行化学成分分析。结果:结合文献报道及质谱数据,共鉴定35个成分,包括10个黄酮类、16个蒽醌类、1个生物碱类、5个皂苷类、2个苯丙素类、1个有机酸类。结论:本方法可快速并全面检测桃核承气汤中的化学成分,可为该经典名方的后续开发提供可靠的数据支撑。Objective:To analyze the chemical constituents of Taohe Chengqi Decoction by UHPLC-Q-TOF-MS.Method:UHPLC-Q-TOF-MS method was used to scan the mass spectrum of Taohe Chengqi Decoction,reference and reference products,and analyze its chemical composition by comparing the chromatogram of reference substance and referring to relevant literature.Results:According to the literature reports and mass spectrometry data,totally of 35 components were identified,including 10 flavonoids,16 anthraquinones,1 alkaloid,5 saponins,2 phenylpropanoids and 1 organic acid.Conclusion:This method can detect the chemical composition in Taohe Chengqi decoction quickly and comprehensively,and can provide reliable data support for the follow-up development of this classic recipe.

关 键 词：桃核承气汤 UHPLC-Q-TOF-MS 化学成分 

分 类 号：TQ[化学工程]