西格列汀与阿卡波糖联合用于2型糖尿病治疗中的效果分析及对患者氧化应激、胰岛功能的影响  

Effect of Sigliptin Combined with Acarbose in the Treatment of Type 2 Diabetes and Its Influence on Oxidative Stress and Islet Function

作　　者：聂吉山 聂慧 鲍宇 NIE Jishan;NIE Hui;BAO Yu(Linyi Third People's Hospital,Linyi 276000,Shandong,China;Linyi Maternal and Child Health Hospital,Linyi 276000,Shandong,China;Shandong Medical College,Linyi 276000,Shandong,China)

机构地区：[1]临沂市第三人民医院,山东临沂276000 [2]临沂市妇幼保健院,山东临沂276000 [3]山东医学高等专科学校,山东临沂276000

出　　处：《系统医学》2025年第2期26-29,共4页Systems Medicine

摘　　要：目的探究在2型糖尿病患者中予以西格列汀、阿卡波糖联合治疗的疗效及对氧化应激、胰岛功能的影响。方法非随机选取2021年2月—2023年6月期间于临沂市第三人民医院治疗的92例2型糖尿病患者为研究对象,根据治疗方案差异均分为两组,每组46例患者。对照组口服阿卡波糖,观察组联合应用西格列汀。比较两组临床疗效、血糖水平、氧化应激水平、胰岛功能、不良反应发生情况。结果与对照组的80.43%(37/46)相比较,观察组治疗总有效率95.65%(44/46)更高,差异有统计学意义(χ^(2)=5.060,P<0.05);治疗后观察组血糖水平、氧化应激水平、胰岛功能优于对照组,差异有统计学意义(P均<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论在2型糖尿病患者中予以西格列汀+阿卡波糖治疗可有效降低血糖,减轻氧化应激反应,促进胰岛功能改善,且安全性高。Objective To explore the effect of combined treatment of sigliptin and acarbose on oxidative stress and pancreatic islet function in patients with type 2 diabetes.Methods Ninety-two patients with type 2 diabetes admitted to Linyi Third People's Hospital from February 2021 to June 2023 were non-randomly selected as the research objects and divided into two groups according to different treatment methods,with forty-six cases in each group.The control group received oral acarbose,while the observation group received a combination of sitagliptin.Compare the clinical efficacy,blood glucose levels,oxidative stress level,islet function,and adverse reactions between two groups.Results The overall response rate of 95.65%(44/46)was higher in the observation group compared to 80.43%(37/46)in the control group,and the difference was statistically significant(χ^(2)=5.060,P<0.05).The blood glucose level,oxidative stress level,and islet function in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Sigliptin+acarbose can effectively reduce blood sugar,alleviate oxidative stress reaction,and promote the improvement of pancreatic islet function in type 2 diabetes patients with high safety.

关 键 词：2型糖尿病 西格列汀 阿卡波糖 血糖 氧化应激水平 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌]