亚胺培南联合多巴胺治疗重症肺炎的疗效及对炎症反应的影响  

The Effect of Imipenem Combined with Dopamine Treatment on the Efficacy and Inflammatory Response in Patients with Severe Pneumonia

作　　者：张林 汪庆路 褚洪文 ZHANG Lin;WANG Qinglu;CHU Hongwen(Department of Intensive Care Medicine,Second People's Hospital of Dezhou City,Dezhou 253000,Shandong,China)

机构地区：[1]德州市第二人民医院重症医学科,山东德州253000

出　　处：《系统医学》2025年第2期30-32,43,共4页Systems Medicine

摘　　要：目的分析亚胺培南联合多巴胺治疗重症肺炎的疗效及对炎症反应的影响。方法非随机选取德州市第二人民医院于2023年1—12月收治的60例重症肺炎患者为研究对象,按治疗方法不同分为常规组(n=30,单用亚胺培南)、观察组(n=30,联合使用亚胺培南与多巴胺),对比两组的临床疗效、肺功能指标水平、免疫指标、炎症反应。结果与常规组70.00%(21/30)相比较,观察组的总有效率96.67%(29/30)较高,差异有统计学意义(χ^(2)=7.680,P<0.05)。与常规组相比较,观察组的肺功能、免疫指标、炎症指标均较优,差异有统计学意义(P均<0.05)。结论亚胺培南与多巴胺的联合应用能够有效减轻炎症反应,改善免疫功能,提升重症肺炎的临床疗效。Objective To analyze the curative effect of imipenem combined with dopamine on severe pneumonia and its effect on inflammation.Methods A total of sixty patients with severe pneumonia admitted to the Second People's Hospital of Dezhou City from January to December 2023 were non-randomly selected as the study subjects,and divided into conventional group(n=30,imipenem alone)and observation group(n=30,imipenem combined with dopamine)according to different treatment methods.The clinical efficacy,lung function index level,immune index and inflammatory response were compared.Results Compared with 70.00%(21/30)of the conventional group,the total effective rate of the observation group 96.67%(29/30)was higher,and the difference was statistically significant(χ^(2)=7.680,P<0.05).Compared with the conventional group,the levels of lung function,immune indexes and inflammation indexes in the observation group were better,the differences were statistically significant(all P<0.05).Conclusion The combination of imipenem and dopamine can effectively reduce inflammation,improve immune function,and enhance the clinical efficacy of severe pneumonia.

关 键 词：亚胺培南 多巴胺 重症肺炎 疗效 炎症反应 

分 类 号：R563.1[医药卫生—呼吸系统]