早期微创手术治疗重症急性胰腺炎对患者免疫功能的影响分析  

Effect of Minimally Invasive Surgery on Immune Function of Patients with Severe Acute Pancreatitis

作　　者：张浩[1,2] 刘珍 ZHANG Hao;LIU Zhen(Inner Mongolia University for Nationalities,Tongliao 028000,Inner Mongolia Autonomous Region,China;Department of Surgery,Section One,Jining Hospital,Xiyuan Hospital,Jining 272100,Shandong,China;Department of General Surgery,Affiliated Hospital of Inner Mongolia University for Nationalities,Tongliao 028000,Inner Mongolia Autonomous Region,China)

机构地区：[1]内蒙古民族大学,内蒙古通辽028000 [2]西苑医院济宁医院外一科,山东济宁272100 [3]内蒙古民族大学附属医院普外科,内蒙古通辽028000

出　　处：《系统医学》2025年第2期58-61,共4页Systems Medicine

摘　　要：目的研究早期微创手术治疗重症急性胰腺炎患者后对其免疫功能的影响。方法非随机选取2021年1月—2023年1月内蒙古民族大学附属医院收治的80例急性胰腺炎患者为研究对象,按照治疗方法不同分为两组,对照组(n=40)实施常规保守疗法治疗,观察组(n=40)实施早期微创手术治疗,比较两组患者血清淀粉酶(serum amylase,AMS)、尿淀粉酶(urinary amylase,UAMY)、白细胞计数(white blood cell count,WBC)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、免疫功能指标、临床症状评分、并发症发生率、治疗总有效率。结果治疗后,观察组AMS、UAMY、WBC、TNF-α、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、临床症状评分均优于对照组,差异有统计学意义(P均<0.05);观察组患者的并发症发生率低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.0%(38/40),高于对照组的70.0%(28/40),差异有统计学意义(χ^(2)=8.658,P<0.05)。结论重症急性胰腺炎患者通过早期微创手术疗法进行治疗,可改善其免疫功能,影响效果良好。Objective To study the effect of early minimally invasive surgery on the immune function of patients with severe acute pancreatitis.Methods Eighty patients with acute pancreatitis admitted to Affiliated Hospital of Inner Mongolia University for Nationalities from January 2021 to January 2023 were non-randomly selected as research objects and divided into two groups according to different treatment methods.The control group(n=40)received conventional conservative treatment,while the observation group(n=40)received early minimally invasive surgical treatment.The serum amylase(AMS),urinary amylase(UAMY),white blood cell count(WBC),tumor necrosis factor-α(TNF-α),immune function,indicators,clinical symptom score,incidence of complications,total effective rate of treatment between two groups were compared.Results After treatment,the AMS,UAMY,WBC,TNF-α,CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and clinical symptom score of the observation group were better than those of the control group,and the differences were statistically significant(all P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 95.0%(38/40),which was higher than 70.0%(28/40)in the control group,and the difference was statistically significant(χ^(2)=8.658,P<0.05).Conclusion Early minimally invasive surgical treatment for patients with severe acute pancreatitis can improve their immune function and have a good impact.

关 键 词：早期微创手术疗法 重症急性胰腺炎 免疫功能 影响效果 

分 类 号：R657.51[医药卫生—外科学]