臭氧联合氟康唑氯化钠注射液耳浴对伴真菌感染的化脓性中耳炎患者听力恢复及复发率、并发症的影响  

The Effect of Ozone Combined with Fluconazole Sodium Chloride Injection Ear Bath on Hearing Recovery,Recurrence Rate,and Complications in Patients with Suppurative Otitis Media Accompanied by Fungal Infection

作　　者：李静 王广元 王霞 LI Jing;WANG Guangyuan;WANG Xia(Yankuang New Journey General Hospital,Jining 273500,Shandong,China)

机构地区：[1]兖矿新里程总医院,山东济宁273500

出　　处：《系统医学》2025年第2期70-72,79,共4页Systems Medicine

摘　　要：目的探究真菌感染的化脓性中耳炎患者采取臭氧与氟康唑氯化钠注射液耳浴联合治疗的价值。方法非随机选取2022年1月—2024年11月兖矿新里程总医院收治的380例真菌感染的化脓性中耳炎患者作为研究对象,按治疗方式分为两组,每组190例。对照组使用氟康唑氯化钠注射液耳浴治疗,观察组使用氟康唑氯化钠注射液耳浴联合臭氧治疗,比较两组的临床疗效、听力功能、并发症发生情况与复发率。结果观察组总有效率为96.84%(184/190),高于对照组的89.47%(170/190),差异有统计学意义(χ^(2)=8.092,P<0.05)。治疗后,观察组气导阈值与骨导阈值分别为(26.84±7.15)dB、(16.42±2.34)dB,均低于对照组的(37.15±8.15)dB、(20.15±2.16)dB,差异有统计学意义(t=13.107、16.145,P均<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(χ^(2)=4.587,P<0.05);观察组复发率为4.12%(7/170),低于对照组的0.54%(1/184),差异有统计学意义(χ^(2)=5.110,P<0.05)。结论针对伴真菌感染的化脓性中耳炎,可在氟康唑氯化钠注射液耳浴的基础上联合实施臭氧治疗,既能提升治疗效果,还能减少并发症与复发情况。Objective To explore the value of ozone combined with fluconazole sodium chloride injection ear bath for fungal infection of suppurative otitis media.Methods 380 patients with suppurative otitis media with fungal infection admitted to Yankuang New Journey General Hospital from January 2022 to December 2024 were non-randomly selected as the study objects and divided into two groups according to treatment methods,with 190 cases in each group.The control group was treated with fluconazole sodium chloride injection ear bath,and the observation group was treated with fluconazole sodium chloride injection ear bath combined with ozone treatment.The clinical efficacy,hearing function,complications and recurrence rate of the two groups were compared.Results The total effective rate of the observation group was 96.84%(184/190),which was higher than 89.47%(170/190)of the control group,and the difference was statistically significant(χ^(2)=8.092,P<0.05).After treatment,the air conduction threshold and bone conduction threshold of the observation group were(26.84±7.15)dB and(16.42±2.34)dB,respectively,which were lower than(37.15±8.15)dB and(20.15±2.16)dB of the control group,and the differences were statistically significant(t=13.107,16.145,both P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(χ^(2)=4.587,P<0.05).The recurrence rate of the observation group was 4.12%(7/170),which was lower than 0.54%(1/184)of the control group,and the difference was statistically significant(χ^(2)=5.110,P<0.05).Conclusion For suppurative otitis media with fungal infection,fluconazole sodium chloride injection ear bath can be combined with ozone therapy,which can not only improve the therapeutic effect,but also reduce complications and recurrence.

关 键 词：化脓性中耳炎 真菌感染 氟康唑氯化钠注射液耳浴 臭氧 临床疗效 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]