血管性认知障碍合并腔隙性脑梗死患者行颈动脉支架植入术的效果分析  

Analysis of the Effect of Carotid Artery Stent Implantation on Patients with Vascular Cognitive Impairment Complicated with Lacunar Cerebral Infarction

作　　者：姜会 李英真 高富娟 JIANG Hui;LI Yingzhen;GAO Fujuan(Department of Neurology,Caoxian People's Hospital,Heze 274400,Shandong,China)

机构地区：[1]曹县人民医院神经内科,山东菏泽274400

出　　处：《系统医学》2025年第2期115-118,共4页Systems Medicine

摘　　要：目的分析血管性认知障碍(vascular cognitive impairment,VCI)合并腔隙性脑梗死(lacunar cerebral infarction,LI)患者行颈动脉支架植入术(carotid artery stenting,CAS)治疗对其生活质量、认知水平的影响。方法非随机选取曹县人民医院于2019年1月—2024年1月收治的62例VCI合并LI患者为研究对象。根据治疗方式的不同,将患者分为常规组(n=31,药物治疗)、手术组(n=31,CAS治疗),观察比较两组患者脑血流灌注参数、认知功能及日常生活能力、血清指标水平。结果治疗前,两组患者血流灌注参数指标、简明精神状态(Mini-Mental State Examination,MMSE)评分、Bathel指数(Barthel Index,BI)、脑损伤血清指标比较,差异无统计学意义(P均>0.05);治疗后,手术组平均通过时间、相对达峰时间、神经元特异性烯醇化酶、内皮素均低于常规组,降钙素基因相关肽水平高于常规组,差异有统计学意义(P均<0.05)。手术组MMSE评分(23.98±2.57)分及BI评分(62.17±3.92)分均高于常规组的(22.52±1.68)分、(59.37±4.63)分,差异有统计学意义(t=2.648、2.570,P均<0.05)。结论CAS治疗方式可有效改善VCI合并LI患者血流灌注与血清指标,有利于提升其认知水平与生活能力。Objective To analyze the effect of carotid artery stenting(CAS)on the quality of life and cognitive level in patients with vascular cognitive impairment(VCI)complicated with lacunar cerebral infarction(LI).Methods A total of sixty-two patients with VCI and LI admitted to Caoxian People's Hospital from January 2019 to January 2024 were non-randomly selected as the study subjects.According to the different treatment methods,the patients were divided into conventional group(n=31,drug treatment)and operation group(n=31,CAS treatment).The cerebral blood perfusion parameters,cognitive function and daily living ability,serum index levels of the two groups were observed and compared.Results Before treatment,there were no significant differences in blood perfusion parameters,Mini-Mental State Examination(MMSE)score,Barthel Index(BI)and serum indexes of brain injury between the two groups(all P>0.05).After treatment,the relative mean transit time,relative time to peak,neuron-specific enolase and endothelin in the operation group were lower than those in the conventional group,the level of calcito-nin gene-related peptide was higher than that in the conventional group,and the differences were statistically significant(all P<0.05).The score of MMSE and BI were 23.98±2.57 and 62.17±3.92 in the operation group,higher than 22.52±1.68 and 59.37±4.63 in the conventional group,the differences were statistically significant(t=2.648,2.570,both P<0.05).Conclusion CAS treatment can effectively improve the blood perfusion and serum indexes of patients with VCI combined with LI,which is conducive to improving the cognitive level and living ability.

关 键 词：颈动脉支架植入术 血管性认知障碍 腔隙性脑梗死 生活质量 

分 类 号：R4[医药卫生—临床医学]