不同剂量纳布啡预防给药对剖宫产腰硬联合麻醉产妇术后镇痛效果的影响  

Effect of Different Doses of Nalbuphine Prophylactic Administration on Postoperative Analgesia in Women Undergoing Combined Lumbar and Rigid Anesthesia for Cesarean Delivery

作　　者：厉洁 谢彦君 颜新锋 LI Jie;XIE Yanjun;YAN Xinfeng(Department of Anesthesiology,Jinan Second Maternal and Child Health Hospital,Jinan 271100,Shandong,China)

机构地区：[1]济南市第二妇幼保健院麻醉科,山东济南271100

出　　处：《系统医学》2025年第2期148-151,共4页Systems Medicine

摘　　要：目的研究不同剂量纳布啡预防给药对剖宫产腰硬联合麻醉产妇术后镇痛效果的影响。方法非随机选取2021年1月—2023年1月在济南市第二妇幼保健院行腰硬联合麻醉下剖宫产的200例产妇为研究对象。根据纳布啡预防给药剂量的不同分为两组,每组100例。对照组实施低剂量纳布啡预防给药。观察组实施高剂量纳布啡预防给药。比较两组产妇术后宫缩痛、切口疼痛程度。结果观察组术后2、4、8、12、24、48 h宫缩痛评分分别为(3.01±0.82)分、(4.41±0.99)分、(5.21±1.15)分、(5.21±0.78)分、(5.21±0.30)分、(4.09±0.18)分,均低于对照组的(4.71±0.91)分、(5.37±0.93)分、(5.81±1.25)分、(5.89±0.87)分、(5.86±0.41)分、(4.81±0.21)分,差异有统计学意义(t=13.878、7.068、3.533、5.820、12.794、26.032,P均<0.05)。观察组产妇术后切口疼痛程度低于对照组,差异有统计学意义(P均<0.05)。结论高剂量纳布啡预防给药对剖宫产腰硬联合麻醉产妇术后镇痛效果较好。Objective To study the effect of different doses of nalbuphine prophylactic administration on postoperative analgesia in women undergoing combined lumbar and rigid anesthesia for cesarean delivery.Methods A total of 200 cases of cesarean delivery under lumbar-rigid combined anesthesia in the Second Maternal and Child Health Hospital of Jinan City from January 2021 to January 2023 were non-randomly selected as the study subjects.According to the different doses of nalbuphine prophylactic administration,they were divided into two groups,with 100 cases in each group.The control group was administered low-dose nalbuphine prophylaxis.In the observation group,high-dose nalbuphine was administered.Compared the degree of postoperative contraction pain and incision pain between the two groups.Results The pain scores for contraction pain in the observation group at 2 h,4 h,8 h,12 h,24 h,and 48 h postoperatively were 3.01±0.82,4.41±0.99,5.21±1.15,5.21±0.78,5.21±0.30,and 4.09±0.18,respectively,which were lower than the control group's 4.71±0.91,5.37±0.93,5.81±1.25,5.89±0.87,5.86±0.41 and 4.81±0.21 in the control group,and the differences were statistically significant(t=13.878,7.068,3.533,5.820,12.794,26.032,all P<0.05).The degree of postoperative maternal incision pain in the observation group was lower than that in the control group,and the differences were statistically significant(all P<0.05).Conclusion High-dose nalbuphine prophylactic administration is more effective for postoperative analgesia in women undergoing combined lumbar and rigid anesthesia for cesarean delivery.

关 键 词：纳布啡 剖宫产 腰硬联合麻醉 镇痛效果 

分 类 号：R614[医药卫生—麻醉学]