基于出血量凝血功能指标评价卡前列素氨丁三醇治疗产后出血的有效性  

The Effectiveness of Carproxin in Treating Postpartum Hemorrhage Based on the Coagulation Function Index of Blood Volume

作　　者：李宁[1] 王晓 邱聪聪 刘玉芹[1] 石凡英 LI Ning;WANG Xiao;QIU Congcong;LIU Yuqin;SHI Fanying(Department of Obstetrical,Binzhou Central Hospital,Binzhou 251700,Shandong,China)

机构地区：[1]滨州市中心医院产科,山东滨州251700

出　　处：《系统医学》2025年第2期156-158,162,共4页Systems Medicine

摘　　要：目的通过出血量凝血功能指标对卡前列素氨丁三醇治疗产后出血的有效性予以评价。方法非随机选取滨州市中医院2021年2月—2023年12月收治的100例产后出血产妇为研究对象,根据治疗方法的差异,将100例产妇分为对照组和观察组,每组各50例。对照组在胎儿娩出后给予缩宫素注射治疗,观察组在胎儿娩出后给予卡前列素氨丁三醇治疗。比较两组出血量、凝血功能指标及不良事件发生情况。结果观察组产后2、4、8、12 h及24 h出血量均低于对照组,观察组产后止血时间短于对照组,差异有统计学意义(P均<0.05);观察组产后24 h的凝血酶原时间为(11.29±1.27)s、部分凝血活酶时间为(31.26±2.84)s,低于对照组的(13.08±1.36)s、(33.02±2.95)s;纤维蛋白原为(3.96±0.57)g/mL,高于对照组的(2.89±0.61)g/mL,差异有统计学意义(t=6.802、3.039、9.063,P均<0.05);观察组不良事件总发生率为2.00%(1/50),低于对照组的14.00%(7/50),差异有统计学意义(χ^(2)=4.891,P<0.05)。结论针对产后出血产妇采用卡前列素氨丁三醇进行治疗,有助于减少产妇的出血量,且止血时间更短,能够有效改善凝血功能指标,且不良事件发生率较低。Objective The effectiveness of carboprost tromethamine in the treatment of postpartum hemorrhage was evaluated by coagulation function index of bleeding volume.Methods A total of 100 parturients with postpartum hemorrhage admitted to Binzhou Hospital of Traditional Chinese Medicine from February 2021 to December 2023 were randomly selected as the research objects.According to the difference of treatment methods,100 parturients were divided into control group and observation group,with 50 cases in each group.The control group received oxytocin for hemostasis after delivery of the fetus,and the observation group received carprost after delivery.Bleeding volume,coagulation function indicators and adverse events were compared in the two groups.Results The postpartum bleeding volume at 2 h,4 h,8 h,12 h and 24 h were lower than those in the control group,and the postpartum hemostasis time in the observation group was shorter than that in the control group,and the differences were statistically significant(all P<0.05);The prothrombin time and partial thromboplastin time of postpartum 24 h in the observation group were(11.29±1.27)s and(31.26±2.84)s,which were lower than(13.08±1.36)s and(33.02±2.95)s in the control group.The fibrinogen was(3.96±0.57)g/mL,which was higher than that of the control group(2.89±0.61)g/mL,and the differences were statistically significant(t=6.802,3.039,9.063,all P<0.05);The overall incidence of adverse events in the observation group was 2.00%(1/50),lower than 14.00%(7/50)in the control group,and the difference was statistically significant(χ^(2)=4.891,P<0.05).Conclusion Carprostanamintotriol is helpful for the postpartum hemorrhage,and the shorter hemostasis time,effectively improving the coagulation function index,and the low incidence of adverse events.

关 键 词：产妇 产后出血 卡前列素氨丁三醇 出血量 凝血功能指标 不良事件 

分 类 号：R71[医药卫生—妇产科学]