不同剂量阿托伐他汀钙结合阿司匹林对老年冠状动脉粥样硬化性心脏病不稳定型心绞痛患者的临床效果分析  

Clinical Effects of Different Doses of Atorvastatin Calcium Combined with Aspirin in Elderly Patients with Coronary Atherosclerotic Heart Disease in Unstable Angina Pectoris

作　　者：陈鑫 刘后春 董方亮[1] CHEN Xin;LIU Houchun;DONG Fangliang(Department of Pharmacy,Lianyungang Fourth People's Hospital,Lianyungang 222021,Jiangsu,China)

机构地区：[1]连云港市第四人民医院药学部,江苏连云港222021

出　　处：《系统医学》2025年第2期183-186,共4页Systems Medicine

摘　　要：目的探讨阿司匹林与不同剂量的阿托伐他汀钙合用于老年冠状动脉粥样硬化性心脏病(简称冠心病)不稳定型心绞痛(unstable angina pectoris,UAP)患者治疗中的临床效果。方法非随机选取2022年7月—2023年7月连云港市第四人民医院收治的84例老年UAP患者为研究对象,根据治疗方法的不同分为两组,每组42例。对照组给予阿托伐他汀钙(10 mg/d)+阿司匹林治疗,观察组予以阿托伐他汀钙(20 mg/d)+阿司匹林治疗。比较两组临床疗效、血脂水平、炎性因子水平。结果观察组临床总有效率为92.86%(39/42),高于对照组的76.19%(32/42),差异有统计学意义(χ^(2)=4.459,P<0.05)。治疗后,两组血脂指标水平、炎性因子水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P均<0.05)。结论老年UAP患者临床治疗中,给予大剂量(20 mg/d)阿托伐他汀钙+阿司匹林的疗效确切,能有效改善血脂水平,降低炎症反应。Objective To investigate the clinical effects of aspirin combined with different doses of atorvastatin calcium in the treatment of elderly patients with unstable angina pectoris(UAP)in coronary atherosclerotic heart disease(coronary heart disease).Methods Eighty-four cases of elderly UAP patients admitted to Lianyungang Fourth People's Hospital from July 2022 to July 2023 were non-randomly selected as the study subjects,and were divided into two groups of forty-two cases each according to the different treatment methods.The control group was given atorvastatin calcium(10 mg/d)+aspirin treatment,and the observation group was given atorvastatin calcium(20 mg/d)+aspirin treatment.Compared the clinical efficacy,lipid levels,and inflammatory factor levels of the two groups.Results The total clinical effective rate of the observation group was 92.86%(39/42),which was higher than 76.19%(32/42)of the control group,and the difference was statistically significant(χ^(2)=4.459,P<0.05).After treatment,the levels of lipid indexes and inflammatory factors in both groups were lower than those before treatment,and the observation group was lower than the control group,and the differences were statistically significant(all P<0.05).Conclusion The efficacy of high-dose(20 mg/d)atorvastatin calcium+aspirin given in the clinical management of elderly patients with UAP is effective in improving lipid levels and reduces inflammatory responses.

关 键 词：阿托伐他汀钙 阿司匹林 冠状动脉粥样硬化性心脏病 不稳定型心绞痛 临床效果 

分 类 号：R4[医药卫生—临床医学]