全固态协同脉冲发生器的设计与研制  

Design and development of a synergistic pulse generator based on all-solid-state switch devices

作　　者：董守龙[1] 朱黎明[1] 岳亚琪 赵立胜 余亮[1] 姚陈果[1] DONG Shoulong;ZHU Liming;YUE Yaqi;ZHAO Lisheng;YU Liang;YAO Chenguo(State Key Laboratory of Power Transmission Equipment&System Security and New Technology,Chongqing University,Chongqing 400030,P.R.China)

机构地区：[1]重庆大学输变电装备技术全国重点实验室,重庆400030

出　　处：《重庆大学学报》2025年第3期1-13,共13页Journal of Chongqing University

基　　金：国家自然科学基金青年科学基金资助项目(51807016,51907011);重庆市自然科学基金面上项目(cstc2020jcyjmsxmX0932);中央高校基本科研业务费(2020CDJYGSX001,2020CDJYGDQ008);重庆市高等教育教学改革研究项目(213052);重庆市研究生科研创新项目(CYB22016)。

摘　　要：不可逆电穿孔肿瘤治疗技术已经在临床应用中取得了较为显著的疗效。最近研究表明,采用高压纳秒脉冲协同低压微秒脉冲可以显著提高消融疗效。文中提出了一种新型的协同脉冲发生器拓扑结构,主要包括2个分别由IGBT和MOSFET作为主开关的Marx电路。通过开关的控制可灵活输出由高压纳秒脉冲和低压微秒脉冲组成的协同脉冲序列,并对其工作原理、电路仿真及原型样机进行了研究。最终采用半导体开关研制了一款参数灵活可调的全固态协同脉冲发生器,并在100Ω电阻负载上对其进行了性能测试,纳秒脉冲参数为电压幅值0~5 kV、脉宽0.2~1μs;微秒脉冲参数为电压幅值0~5 kV、脉宽10~100μs,能够满足协同脉冲消融肿瘤的实验需求。The irreversible electroporation technique has demonstrated remarkable efficacy in tumor treatment.Recent studies indicate that combining high-voltage nanosecond pulses with low-voltage microsecond pulses can significantly improve ablation effectiveness.To address this,this paper proposes a novel topology for a synergistic pulse generator,consisting of two Marx circuits utilizing insulated-gate bipolar transistors(IGBT)and metal-oxidesemiconductor field-effect transistors(MOSFETs)as main switching devices.By flexibly controlling these switches,the generator can produce a synergistic pulse sequence comprising high-voltage nanosecond pulses and low-voltage microsecond pulses.This study explores the generator’s operating principle,circuit simulation,and prototype development.The resulting all-solid-state synergistic pulse generator features flexible and adjustable parameters,leveraging semiconductor switches for improved performance.Its functionality is evaluated using a 100Ωresistance load,yielding the following pulse characteristics:nanosecond pulses with voltage amplitudes of 0 kV to 15 kV and pulse widths of 200 ns to 1μs,and microsecond pulses with voltage amplitudes of 0 kV to 5 kV and pulse widths of 10μs to 100μs.These parameters meet the experimental requirements for synergistic pulsing in tumor ablation.

关 键 词：脉冲功率技术 MARX发生器 全固态 协同脉冲 肿瘤消融 

分 类 号：TN78[电子电信—电路与系统] TM832[电气工程—高电压与绝缘技术]