不同剂量羟考酮术前用药对腹腔镜胆囊切除术患者的影响  

Effects of Different Doses of Oxycodone on Acute Pain and Stress Response After Laparoscopic Cholecystectomy

作　　者：贾伟 何凌锋[2] 雷拯 JIA Wei;HE Lingfeng;LEI Zheng(Department of Anesthesiology,Wuhan Jihe Hospital,Wuhan 430000,Hubei,China;Department of Anesthesiology,Hubei Armed Police Corps Hospital,Wuhan 430000,Hubei,China)

机构地区：[1]武汉市济和医院麻醉科,湖北武汉430000 [2]武警湖北总队医院麻醉科,湖北武汉430000

出　　处：《系统医学》2025年第3期66-69,共4页Systems Medicine

摘　　要：目的评估不同剂量羟考酮术前用药对腹腔镜胆囊切除术患者的影响。方法非随机选取武汉市济和医院于2020年1月—2022年12月收治的90例接受腹腔镜胆囊切除术的患者为研究对象。所有患者均接受羟考酮静脉推注+1.5 mg/kg丙泊酚诱导麻醉,按照羟考酮剂量分为3组。包括:羟考酮剂量为0.05 mg/kg(A组,n=30),羟考酮剂量为0.08 mg/kg(B组,n=30),羟考酮剂量为0.12 mg/kg(C组,n=30)。比较3组间镇痛效果、镇静效果、术后不良反应。结果C组患者术后5 min、1 h、4 h视觉模拟评分低于A组、B组患者;B组患者术后5 min、1 h、4 h的VAS低于A组,差异有统计学意义(P均<0.001);C组患者术后5 min、1 h、4 h儿科临床镇静评分评分值高于A组、B组;B组术后5 min、1 h、4 h的临床镇静评分高于A组,差异有统计学意义(P均<0.001)。A组患者术后并发症总发生率为3.33%(1/30),B组为6.67%(2/30),均低于C组的26.67%(8/30),差异有统计学意义(χ^(2)=4.706、4.320,P均<0.05)。结论在腹腔镜胆囊切除术前采用0.08 mg/kg羟考酮静脉推注+1.5 mg/kg丙泊酚诱导麻醉镇痛效果较好。Objective To evaluate the effect of different doses of oxycodone on patients undergoing laparoscopic cholecystectomy before operation.Methods A total of ninety patients who underwent who underwent laparoscopic cholecystectomy in Wuhan Jihe Hospital from January 2020 to December 2022 were non-randomly selected as the research objects.All patients received oxycodone intravenous injection+1.5 mg/kg propofol induction anesthesia,and were divided into 3 groups according to the dose of oxycodone.The dose of oxycodone was 0.05 mg/kg(group A,n=30),0.08 mg/kg(group B,n=30),and 0.12 mg/kg(group C,n=30).The analgesic effect,sedative effect and postoperative adverse reaction were compared among the three groups.Results The Visual Analogue Scale scores of patients in group C were lower than those in group A and group B at 5 min,1 h and 4 h after operation.The VAS of group B was lower than that of group A at 5 min,1 h and 4 h after operation,and the differences were statistically significant(all P<0.001).The scores of Ramsay Sedation Scores in group C were higher than those in group A and group B at 5 min,1 h and 4 h after operation.The Ramsay Sedation Scores at 5 min,1 h and 4 h after operation in group B were higher than those in group A,and the differences were statistically significant(all P<0.001).The total incidence of postoperative complications was 3.33%(1/30)in group A and 6.67%(2/30)in group B,which were both lower than 26.67%(8/30)in group C,and the differences were statistically significant(χ^(2)=4.706,4.320,both P<0.05).Conclusion The analgesic effect of 0.08 mg/kg oxycodone intravenous injection+1.5 mg/kg propofol induction anesthesia before laparoscopic cholecystectomy is better.

关 键 词：羟考酮 术前用药 腹腔镜胆囊切除术 

分 类 号：R4[医药卫生—临床医学]