胺碘酮治疗急诊冠心病快速心律失常的疗效及安全性  

Efficacy and Safety of Amiodarone in the Treatment of Tachyarrhythmia in Emergency Coronary Heart Disease

作　　者：薛华军 申前进 徐广玉 XUE Huajun;SHEN Qianjin;XU Guangyu(Department of Emergency,Yifu Hospital Affiliated to Nanjing Medical University,Nanjing 211100,Jiangsu,China)

机构地区：[1]南京医科大学附属逸夫医院急诊科,江苏南京211100

出　　处：《系统医学》2025年第3期92-95,共4页Systems Medicine

摘　　要：目的探讨胺碘酮用于急诊临床治疗冠状动脉粥样硬化性心脏病(简称冠心病)快速心律失常的效果及安全性。方法非随机选取2022年1月—2023年12月南京医科大学附属逸夫医院急诊科收治的82例冠心病快速心律失常患者为研究对象,按照治疗方案不同将患者分为两组,每组各41例。对照组采用普罗帕酮进行治疗,观察组则使用胺碘酮。比较两组在临床疗效、心电图检查指标、心功能检查指标以及不良反应发生情况方面的差异。结果观察组总有效率达97.56%(40/41),较对照组的78.05%(32/41)更高,差异有统计学意义(χ^(2)=7.289,P<0.05)。用药24 h后,观察组心率低于对照组Q-T间期、P-R间期指标较对照组更优;左室射血分数高于对照组,左室收缩末期内径、左室舒张末期内径低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论在急诊临床中,采用胺碘酮药物治疗冠心病快速心律失常效果确切。该药物可有效改善患者的心电图与心功能指标,且不良反应较少,值得借鉴。Objective To investigate the effect and safety of amiodarone in emergency clinical treatment of coronary atherosclerotic heart disease(coronary heart disease)with rapid arrhythmia.Methods From January 2022 to December 2023,eighty-two patients with tachyarrhythmia of coronary heart disease admitted to the emergency department of Yifu Hospital Affiliated to Nanjing Medical University were non-randomly selected as the research objects,and divided into two groups according to different treatment methods,with forty-one cases in each group.The patients in the control group were treated with propafenone,while the patients in the observation group were treated with amiodarone.The differences in clinical efficacy,electrocardiogram examination indexes,cardiac function examination indexes and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.56%(40/41),which was higher than 78.05%(32/41)of the control group,and the difference was statistically significant(χ^(2)=7.289,P<0.05).At 24 h after treatment,the heart rate of the observation group was lower than that of the control group,and the indexes of Q-T interval and P-R interval were better than those of the control group;the left ventricular ejection fraction was higher than that of the control group,and the left ventricular end-systolic diameter and left ventricular end-diastolic diameter were lower than those of the control group,and the differences were statistically significant(all P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In emergency clinic,amiodarone is effective in the treatment of tachyarrhythmia of coronary heart disease.The drug can effectively improve the electrocardiogram and cardiac function indexes of patients,and has fewer adverse reactions,which is worthy of reference.

关 键 词：胺碘酮 冠心病 心律失常 安全性 

分 类 号：R541[医药卫生—心血管疾病]