重症肺炎疾病治疗中采用美罗培南与亚胺培南的临床有效性分析  

Clinical Effectiveness Analysis of Meropenem and Imipenem in the Treatment of Severe Pneumonia

作　　者：刘海鹏 韩纪林 LIU Haipeng;HAN Jilin(Department of Pharmacy,Laiwu Central Hospital,Shandong Health Care Group,Jinan 271103,Shandong,China)

机构地区：[1]山东颐养健康集团莱芜中心医院药剂科,山东济南271103

出　　处：《系统医学》2025年第3期185-188,共4页Systems Medicine

摘　　要：目的探讨美罗培南药物以及亚胺培南治疗重症肺炎的临床效果。方法非随机选取山东颐养健康集团莱芜中心医院于2021年2月—2023年7月收治的120例重症肺炎患者为研究对象。按治疗方法不同分为两组,参照组(60例)采用亚胺培南治疗,研究组(60例)采用美罗培南治疗。对比两组疗效、临床肺部感染评分(Clinical Pulmonary Infection Score,CPIS)、临床症状消失时间、炎性因子水平。结果研究组治疗总有效率为98.33%(59/60),高于参照组86.67%的(52/60),差异有统计学意义(χ^(2)=4.324,P<0.05);治疗后,与参照组比较,研究组CPIS评分更低,临床症状消失时间更短,炎性因子水平更低,差异有统计学意义(P均<0.05)。结论在重症肺炎患者治疗中,同亚胺培南比较,美罗培南的合理应用,可明显提升患者的疗效,并显著改善患者的症状以及炎症因子水平。Objective To investigate the clinical effects of meropenem and imipenem in the treatment of severe pneumonia.Methods 120 patients with severe pneumonia admitted to Laiwu Central Hospital,Shandong Health Care Group from February 2021 to July 2023 were non-randomly selected as study objects.All patients were divided into two groups according to the different treatment methods.Reference group(60 cases)was treated withimipenem;study group(60 cases)was treated with meropenem.The effective rate,Clinical Pulmonary Infection Score(CPIS),time for clinical symptom to disappear,and inflammatory factor level of the two groups of patients with severe pneumonia were compared.Results The therapeutic effect of the study group was 98.33%(59/60),which was higher than 86.67%(52/60)of the reference group,and the difference was statistically significant(χ^(2)=4.324,P<0.05).After treatment,the CPIS of the study group was lower,the time for clinical symptom to disappear in the study group was shorter,the levels of inflammatory factors of the study group were lower compared with the reference group,and the differences were statistically significant(all P<0.05).Conclusion Compared with imipenem,meropenem can significantly improve the therapeutic effect of patients with severe pneumonia during treatment,and significantly improve the level of symptoms and inflammatory factors.

关 键 词：重症肺炎疾病 美罗培南 亚胺培南 治疗效果 临床肺部感染评分 临床症状消失时间 炎性因子 

分 类 号：R9[医药卫生—药学]