2-氯咪唑氯化物活化的羧酸化合物的Stille交叉偶联反应  

Stille Cross-coupling Reaction on Carboxylic Acids Using 2-Chloroimidazolium Chloride as An Activation Reagent

作　　者：郑伟翔 刘子琪 邹胜[1] 高基 周莉[4] 王启卫[1,2,3] ZHENG Weixiang;LIU Ziqi;ZOU Sheng;GAO Ji;ZHOU Li;WANG Qiwei(Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China;University of Chinese Academy of Sciences,Beijing 100049,China;Department of Chemistry,Xihua University,Chengdu 610039,China;Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]中国科学院大学,北京100049 [3]西华大学理学院,四川成都610039 [4]中国科学院成都生物研究所,四川成都610041

出　　处：《合成化学》2025年第2期73-80,共8页Chinese Journal of Synthetic Chemistry

基　　金：国家重点研发计划项目(2023YFB3812400)。

摘　　要：羧酸类化合物是一类商业上丰富、结构多样且稳定,常用于有机合成中的原料。目前还未见直接以羧酸化合物为原料的Stille交叉偶联反应的报道。以羧酸和有机锡化合物为原料,2-氯咪唑氯化物(IPrCl-Cl)为活化试剂,Cs_(2)CO_(3)为碱,甲苯为溶剂,在温度为90℃的Pd(PPh_(3))_(2)Cl_(2)催化下,通过Stille交叉偶联反应合成了15个芳基酮化合物(3a~3o),收率最高达67%,所有产物结构由^(1)H NMR,^(13)C NMR确证。Carboxylic acids are commercially abundant and structurally diverse,bench-stable feedstock chemicals commonly used in organic synthesis.There was no report on the Stille cross-coupling reaction using carboxylic acid compounds as raw materials.In this study,we report an efficient Stille coupling reaction of carboxylic acids with organotin compounds in toluene in the presence of IPrCl-Cl,Pd(PPh_(3))_(2)Cl_(2),and Cs_(2)CO_(3) at 90℃to give fifteen corresponding aryl ketones(3a~3o).The yield up to 67%.The structures of all products were confirmed by ^(1)H NMR,^(13)C NMR.

关 键 词：羧酸化合物 有机锡化合物 2-氯咪唑氯化物 芳基酮 Stille交叉偶联反应 

分 类 号：O626.1[理学—有机化学]