Organ Preservation:History,Advancements,and Perspectives  

作　　者：Xinmeng Liu Zhiquan Shu Liming Zhang Haoyue Li Jing Yang Lei Zhang 

机构地区：[1]Department of Biochemical Engineering,Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(MOE),School of Chemical Engineering and Technology,Tianjin University,Tianjin 300350,China [2]State Key Laboratory of Synthetic Biology,Tianjin 300072,China [3]School of Engineering and Technology,University of Washington Tacoma,Tacoma,WA 98402,USA [4]Haihe Laboratory of Sustainable Chemical Transfonnations,Tianjin 300192,China

出　　处：《Engineering》2025年第1期112-134,共23页工程(英文)

基　　金：financially supported by the National Key Research and Development Program of China(2022YFC2100800);the National Natural Science Foundation of China(22478296,22078238,52373117,and U23B20121);the Haihe Laboratory of Sustainable Chemical Transformations(24HHWCSS00005);the Open Funding Project of the National Key Laboratory of Biochemical Engineering。

摘　　要：Recent advances in organ transplantation,regenerative medicine,and drug discovery have emphasized the critical importance of effective preservation techniques for organs.Despite these advances,current preservation techniques have significant limitations in maintaining the viability and functional efficacy of organs over the long term.As a result,there is a pressing need to develop reliable and efficient preservation strategies for organs.Currently,the clinical standard for organ preservation involves the use of static cold storage and organ machine perfusion,but these methods can only preserve organs for a couple of days or even a few hours.Notably,the development of cryobiology has yielded promising alternatives.In this review,we aim to provide a comprehensive overview of the progression of organ preservation methods,while emphasizing the limitations of traditional approaches.Moreover,we evaluate advanced preservation techniques for organs,including kidneys,livers,hearts,lungs,and intestines.Furthermore,we share a progress perspective on the future of organ preservation,with the ultimate goal of achieving viable long-term preservation to address the pressing issue of organ shortage.

关 键 词：Organ preservation Organ machine perfusion Static cold storage VITRIFICATION Preservation solution 

分 类 号：R617[医药卫生—外科学]