定坤丹联合重组人生长激素对卵巢低反应患者体外受精-胚胎移植结局的影响  

The Effects of Dingkundan Combined with Recombinant Human Growth Hormone on the Outcomes of in Vitro Fertilization-Embryo Transfer in Patients with Poor Ovarian Response

作　　者：张玉菡 赵琰[1] 陈晶晶[1] 夏雷震 苏琼[1] ZHANG Yu-han;ZHAO Yan;CHEN Jing-jing;XIA Lei-zhen;SU Qiong(Jiangxi Maternal and Child Health Hospital,Nanchang 330038)

机构地区：[1]江西省妇幼保健院,南昌330038

出　　处：《实用中西医结合临床》2025年第6期5-8,55,共5页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

基　　金：江西省中医药管理局科技计划项目(编号:2022B163);江西省自然科学基金项目(编号:20224BAB216026);江西省省级临床重点专科建设项目(编号:02000200100)。

摘　　要：目的探讨促排卵过程中联合使用定坤丹及重组人生长激素对卵巢低反应患者体外受精-胚胎移植结局的影响。方法回顾性分析2020年7月至2023年7月江西省妇幼保健院辅助生殖中心行高孕激素状态下促排卵方案(PPOS)的744例卵巢低反应患者临床资料,按照是否联用定坤丹与重组人生长激素注射液分为治疗组(n=235)与对照组(n=509)。比较两组一般资料、新鲜周期超促排卵情况、新鲜周期胚胎培养情况及首次复苏胚胎移植结局。结果两组年龄、体质量指数(BMI)对比,差异无统计学意义(P>0.05);治疗组窦卵泡计数(AFC)、抗缪勒管激素(AMH)均低于对照组(P<0.05)。在新鲜周期促排卵过程中,两组促性腺激素(Gn)总剂量、Gn时间、扳机日雌二醇(E2)水平对比,差异无统计学意义(P>0.05);治疗组扳机日内膜厚度小于对照组,获卵数少于对照组(P<0.05)。两组正常受精率、正常卵裂率、可移植囊胚形成率、可移植胚胎数对比,差异无统计学意义(P>0.05);治疗组卵母细胞胞浆内单精子显微注射(ICSI)卵子成熟率、优质胚胎率均高于对照组(P<0.05)。两组HCG阳性率、生化流产率、种植率、临床妊娠率对比,差异无统计学意义(P>0.05);治疗组多胎率低于对照组(P<0.05)。结论PPOS方案促排卵期间联用定坤丹及生长激素可提高ICSI卵子成熟率、优质胚胎率,提示定坤丹联用生长激素对卵子质量、胚胎质量有一定改善作用。Objective To investigate the effects of combination of Dingkundan and recombinant human growth hormone on the outcomes of in vitro fertilization and embryo transfer in patients with poor ovarian response during ovulation induction.Methods A retrospective analysis was conducted on the clinical data of 744 patients with poor ovarian response who underwent high progesterone treated with Progestin Primed Ovarian Stimulation(PPOS)in Assisted Reproductive Center of Jiangxi Maternal and Child Health Hospital from July 2020 to July 2023.The patients were divided into a treatment group(n=235)and a control group(n=509)according to whether they were treated with Dingkundan and recombinant human growth hormone injection.Compared the general information,fresh cycle superovulation status,fresh cycle embryo culture status and outcomes of first resuscitation embryo transfer between two groups.Results There was no statistically significant difference in age and body mass index(BMI)between the two groups(P>0.05).The antral follicle count(AFC)and anti-Müllerian hormone(AMH)in the treatment group were lower than those in the control group(P<0.05).In the process of fresh cycle ovulation,the total dose of gonadotropin(Gn),the time of Gn and the level of estradiol(E2)on the trigger day of the two groups had no statistical significance(P>0.05).The inner membrane thickness of trigger day in the treatment group was lower than that in the control group(P<0.05).There was no significant difference in normal fertilization rate,normal cleavage rate,transplantable blastocyst formation rate and number of transplantable embryos between the two groups(P>0.05).The maturation rate of intracytoplasmic sperm injection(ICSI)eggs and high-quality embryo rate in the treatment group were higher than those in the control group(P<0.05).There was no statistically significant difference in HCG positive rate,biochemical abortion rate,implantation rate and clinical pregnancy rate between the two groups(P>0.05).The probability of multiple births in the treatmen

关 键 词：卵巢低反应 定坤丹 生长激素 

分 类 号：R714.8[医药卫生—妇产科学]