不同剂量生长抑素联合雷尼替丁注射液治疗胰腺炎的临床研究  

Clinical Study on Different Doses of Somatostatin Combined with Ranitidine Injection in the Treatment of Pancreatitis

作　　者：沈宽波 邓昌华 田贵波 SHEN Kuanbo;DENG Changhua;TIAN Guibo(Department of Hepatobiliary and Pancreatic Surgery,Guihang Anshun 302 Hospital,Anshun 561099,Guizhou,China)

机构地区：[1]贵航安顺三〇二医院肝胆胰腺外科,贵州安顺561099

出　　处：《系统医学》2025年第6期107-110,共4页Systems Medicine

摘　　要：目的探讨不同剂量生长抑素联合雷尼替丁注射液治疗胰腺炎的临床效果和安全性。方法非随机选取2020年1月—2021年12月贵航安顺三〇二医院收治的120例胰腺炎患者为研究对象,按治疗方案为3组,每组40例。对照组给予常规治疗;低剂量组在对照组基础上加用生长抑素25μg/h、雷尼替丁50 mg静脉滴注;高剂量组在对照组基础上加用生长抑素50μg/h、雷尼替丁100 mg静脉滴注。比较3组临床症状、炎症指标水平、并发症发生率、住院时间、不良反应。结果治疗后,3组临床症状改善率、胰腺酶降低率、炎症指标水平、并发症发生率比较,差异有统计学意义(P均<0.05)。高剂量组住院时间为(12.5±3.2)d,短于对照组的(18.7±4.5)d和低剂量组的(15.3±3.8)d,差异有统计学意义(F=25.754,P<0.05),高剂量组与低剂量组住院时间比较,差异有统计学差异(t=7.101,P<0.05)。3组不良反应发生率比较,差异无统计学意义(P>0.05)。结论生长抑素联合雷尼替丁注射液治疗胰腺炎效果好,能够有效缓解症状,高剂量生长抑素联合雷尼替丁注射液降低炎症反应、缩短住院时间方面优于低剂量。Objective To investigate the therapeutic effectiveness and safety profile of varying dosages of different doses of somatostatin combined with ranitidine injection in the management of pancreatic inflammation.Methods A total of 120 cases of pancreatitis patients admitted to Guihang Anshun 302 Hospital from January 2020 to December 2021 were non-randomly selected as the study subjects,which were divided into three groups according to the treat-ment plan,with 40 cases in each group.The control group underwent standard therapy.The low-dose group received somatostatin 25μg/h and ranitidine 50 mg intravenously.The high-dose group received somatostatin 50μg/h and ra-nitidine 100 mg intravenously.Clinical symptoms,inflammatory index levels,complication rate,hospitalisation time and adverse reactions were compared among the three groups.Results After treatment,there were statistically signifi-cant differences in the rates of clinical symptom improvement,pancreatic enzyme reduction,inflammatory index lev-els,and complication rates among the three groups(all P<0.05).The length of hospitalisation in the high-dose group was(12.5±3.2)d,which was shorter than(18.7±4.5)d in the control group and(15.3±3.8)d in the low-dose group,re-spectively,and the difference was statistically significant(F=25.754,P<0.05),and there was statistically significant difference in length of hospitalisation between the high dose group and the low dose group(t=7.101,P<0.05).The dif-ference in the incidence of adverse reactions among the 3 groups was not statistically significant(P>0.05).Conclusion Growth inhibitor combined with ranitidine injection is effective in the treatment of pancreatitis and can effectively re-lieve symptoms,and the high dose of growth inhibitor combined with ranitidine injection is superior to the low dose in terms of lowering the inflammatory response and shortening the length of hospitalisation.

关 键 词：生长抑素 雷尼替丁 胰腺炎 临床研究 

分 类 号：R4[医药卫生—临床医学]