枸橼酸氢钾钠颗粒结合体外碎石术治疗对肾结石患者的结石清除率及复发率的影响  

Effect of Potassium Sodium Hydrogen Citrate Granules Combined with Extracorporeal Lithotripsy on Stone Clearance Rate and Recurrence Rate in Patients with Renal Calculi

作　　者：俞宇宙 吴剑平 胡明进 刘启弘 YU Yuzhou;WU Jianping;HU Mingjin;LIU Qihong(Department of Urology,Nanjing Lishui People′s Hospital(Zhongda Hospital Lishui Branch,Southeast University),Lishui 211200,Jiangsu,China)

机构地区：[1]南京市溧水区人民医院(东南大学附属中大医院溧水分院)泌尿外科,江苏溧水211200

出　　处：《系统医学》2025年第6期115-118,共4页Systems Medicine

摘　　要：目的探讨对肾结石患者予以枸橼酸氢钾钠颗粒与体外碎石术(extracorporeal shock wave lithotripsy,ESWL)结合治疗的疗效及对结石清除率及复发率的影响。方法非随机选取2023年1—12月南京市溧水区人民医院泌尿外科收治的肾结石患者60例为研究对象,按照治疗方式进行分组,每组30例,对照组予以ESWL治疗,观察组予以ESWL与枸橼酸氢钾钠颗粒结合治疗。对比两组结石清除率、肾绞痛发生率、结石首次排出时间、结石总复发率、肾功能指标。结果观察组结石清除率为96.67%(29/30),高于对照组的73.33%(22/30),肾绞痛发生率为3.33%(1/30),低于对照组的30.00%(9/30),差异有统计学意义(χ^(2)=4.705、5.880,P均<0.05),观察组结石首次排出时间较对照组短,差异有统计学意义(P<0.05);治疗后两组中性粒细胞明胶酶相关脂质运载蛋白、胱抑素C水平下降,血肌酐水平上升,且观察组优于对照组,差异有统计学意义(P均<0.05);观察组治疗后结石总复发率较对照组低,差异有统计学意义(P均<0.05)。结论对肾结石患者予以枸橼酸氢钾钠颗粒与ESWL结合治疗效果显著,不仅可促进结石清除率提升,同时还能改善肾功能状态,并缓解肾绞痛,对预防结石复发具有至关重要意义。Objective To investigate the effect of the combination of sodium hydrogen potassium citrate particles and extracorporeal shock wave lithotripsy(ESWL)on the stone clearance rate and recurrence rate of renal stone patients.Methods Sixty patients with kidney stones admitted to the Department of Urology of Lishui District People's Hospital in Nanjing from January 2023 to December 2023 were non-randomly selected as the research objects,and divieded into two groups with thirty cases each according to the treatment modality;the control group was treated with ESWL,and the observation group was treated with the combination of ESWL and sodium potassium citrate particles.The total recurrence rate of stones,incidence of renal colic,first discharge time,total stone recurrence rate and renal function index were compared.Results The stone clearance rate of the observation group was 96.67%(29/30),higher than 73.33%(22/30)of the control group,the incidence rate of renal colic was 3.33%(1/30)in the observation group,which was lower than 3.00%(9/30)in the control group,and the differences were statistically significant(χ^(2)=4.705,5.880,both P<0.05).The time of first stone discharge in the observation group,shorter than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of NGAL and Cys-C in the two groups showed a decreasing trend,and the level of Scr showed an increasing trend,and the the observation group was greater than the control group,the differences were statistically significant(all P<0.05).The total rate of recurrence of stones in the observation group after treatment was lower compared with that in the control group,the difference was statistically significant(P<0.05).Conclusion The combination of sodium hydrogen potassium citrate granules and ESWL is effective in treating renal stone patients,which not only promotes the stone removal rate,but also improves renal function and relieves renal colic,which is crucial to prevent the recurrence of stones and accelerat

关 键 词：肾结石 枸橼酸氢钾钠颗粒 体外碎石术 结石清除率 结石复发率 肾功能 

分 类 号：R699.2[医药卫生—泌尿科学]