琥珀酸亚铁联合维生素C治疗妊娠期缺铁性贫血的效果及其对不良妊娠结局的影响  

Effect of Ferrous Succinate Combined with Vitamin C in the Treatment of Iron Deficiency Anemia During Pregnancy and Its Effect on Adverse Pregnancy Outcomes

作　　者：田丽娜 刘自闫 梁丽丽 TIAN Lina;LIU Ziyan;LIANG Lili(Department of Obstetrics and Gynecology,Capital Medical University Shijingshan Teaching Hospital Beijing Shijingshan Hospital,Beijing 100043,China)

机构地区：[1]首都医科大学石景山教学医院北京市石景山医院妇产科,北京100043

出　　处：《系统医学》2025年第6期165-168,共4页Systems Medicine

摘　　要：目的分析琥珀酸亚铁联合维生素C治疗妊娠期缺铁性贫血的效果及其对不良妊娠结局的影响。方法非随机选取2022年1月—2024年1月首都医科大学石景山教学医院北京市石景山医院接收的142例妊娠期缺铁性贫血患者为研究对象,按照不同的治疗方式将患者分为两组,各71例。对照组予以琥珀酸亚铁治疗,观察组予以琥珀酸亚铁+维生素C治疗。对比两组血常规指标、铁代谢指标、免疫指标的改善情况及不良妊娠结局。结果观察组血红蛋白、红细胞、平均红细胞血红蛋白浓度及红细胞平均体积改善情况均优于对照组,差异有统计学意义(P均<0.05)。观察组转铁蛋白饱和度、可溶性转铁蛋白受体水平均优于对照组,差异有统计学意义(P均<0.05)。观察组各项免疫功能改善情况均优于对照组,差异有统计学意义(P均<0.05)。观察组不良妊娠结局总发生率为2.82%(2/71),低于对照组的16.90%(12/71),差异有统计学意义(χ^(2)=7.924,P<0.05)。结论采取琥珀酸亚铁联合维生素C治疗妊娠期缺铁性贫血具有明显效果,其不仅有利于改善患者的血常规指标,还能够减少不良妊娠发生情况,具有一定的研究意义。Objective To analyze the effect of ferrous succinate combined with vitamin C in the treatment of iron defi-ciency anemia during pregnancy and its effect on adverse pregnancy outcomes.Methods From January 2022 to Janu-ary 2024,142 patients with iron deficiency anemia during pregnancy received by Capital Medical University Shijing-shan Teaching Hospital Beijing Shijingshan Hospital were non-randomly selected as the research objects.According to different treatment methods,the patients were divided into two groups,71 cases in each group.The control group was treated with ferrous succinate,and the observation group was treated with ferrous succinate+vitamin C.The im-provement of blood routine indexes,iron metabolism indexes,immune indexes and adverse pregnancy outcomes were compared between the two groups.Results The improvement of hemoglobin,red blood cells,mean red blood cell he-moglobin concentration and mean red blood cell volume in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The levels of transferrin saturation and soluble transferrin receptor in the observation group were better than those in the control group,and the differences were sta-tistically significant(both P<0.05).The improvement of immune function in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The total incidence of adverse pregnancy outcomes in the observation group was 2.82%(2/71),which was lower than 16.90%(12/71)in the control group,and the difference was statistically significant(χ^(2)=7.924,P<0.05).Conclusion Ferrous succinate combined with vitamin C has a significant effect in the treatment of iron deficiency anemia during pregnancy.It is not only ben-eficial to improve the blood routine indexes of patients,but also can reduce the incidence of adverse pregnancy,which has certain research significance.

关 键 词：妊娠期缺铁性贫血 琥珀酸亚铁 维生素C 铁代谢指标 不良妊娠结局 

分 类 号：R59[医药卫生—内科学]