血清C1q/肿瘤坏死因子相关蛋白、趋化素样因子-1对子痫前期的诊断效能  

Serum levels of CTRP6 and CKLF1 in patients with preeclampsia and their diagnostic efficacy

作　　者：徐然 吴亚男 王建美 XU Ran;WU Yanan;WANG Jianmei(Department of Obstetrics,Hebei Petro China Central Hospital,Langfang,Hebei 065000,China)

机构地区：[1]河北中石油中心医院产科,河北廊坊065000

出　　处：《安徽医药》2025年第5期987-990,共4页Anhui Medical and Pharmaceutical Journal

基　　金：廊坊市科技支撑计划项目(2022013125)。

摘　　要：目的探讨子痫前期(PE)病人血清C1q/肿瘤坏死因子相关蛋白(CTRP6)、趋化素样因子-1(CKLF1)的表达水平及其对PE的诊断效能。方法选取2021年12月至2022年10月河北中石油中心医院确诊并收治的PE孕妇为研究对象,根据病情严重程度,将PE病人分为轻度PE组(35例)和重度PE组(35例),另选取同期收治的正常妊娠期孕妇35例作为对照组。酶联免疫吸附分析(ELISA)检测所有研究对象血清CTRP6、CKLF1表达水平;Pearson相关性分析PE孕妇血清CTRP6与CKLF1之间的相关性;通过受试者操作特征曲线(ROC曲线)探讨CTRP6、CKLF1及联合检测对PE发生的诊断价值;logistic回归分析重度PE发生的影响因素。结果对照组、轻度PE组、重度PE组孕妇收缩压[(101.71±12.23)mmHg、(143.39±16.23)mmHg、(186.88±21.34)mmHg]、舒张压[(67.29±9.37)mmHg、(94.16±8.91)mmHg、(116.22±11.34)mmHg]、24 h尿蛋白水平[(0.19±0.04)g、(1.20±0.23)g、(2.35±0.41)g]及血清CKLF1水平[(29.63±4.17)ng/L、(31.65±3.61)ng/L、(34.77±6.75)ng/L]依次升高(P<0.05),血清CTRP6水平[(645.29±61.40)μg/L、(612.63±33.98)μg/L、(510.23±39.79)μg/L]依次降低(P<0.05);Pearson相关性分析表明,PE病人血清CTRP6与CKLF1呈负相关(r=−0.45,P<0.001);血清CTRP6、CKLF1诊断PE的曲线下面积(AUC)分别为0.74,0.68,其灵敏度分别为62.9%,64.3%,特异度分别为37.2%,68.5%;两者联合诊断PE的AUC为0.87,其灵敏度、特异度分别为71.4%、68.5%;多因素logistic回归分析表明,CTRP6、CKLF1是影响重度PE发生的危险因素(P<0.05)。结论PE病人血清CTRP6水平显著降低,CKLF1水平显著升高,且两者联合检测对PE的发生具有较高的诊断效能。Objective To investigate the expression levels of C1q/tumor necrosis factor-related protein(CTRP6)and chemokine-like factor-1(CKLF1)in serum of patients with preeclampsia(PE)and their diagnostic efficacy for PE.Methods The PE pregnant women who were diagnosed and treated in Hebei Petro China Central Hospital from December 2021 to October 2022 were regarded as the study subjects,according to the severity of the disease,PE patients were grouped into mild PE group(35 cases)and severe PE group(35 cases),in addition,35 normal pregnant women were regarded as the control group.The the expression levels of CTRP6 and CKLF1 in serum of all subjects were detected by enzyme-linked immunosorbent assay(ELISA);Pearson correlation was applied to analyze the correlation between CTRP6 and CKLF1 in the serum of PE pregnant women;receiver operating characteristic curve(ROC)was applied to explore the diagnostic value of CTRP6,CKLF1 and combined detection for PE;logistic regression was applied to analyze the influencing factors of severe PE.Results Systolic blood pressure[(101.71±12.23)mmHg,(143.39±16.23)mmHg,(186.88±21.34)mmHg],diastolic blood pressure[(67.29±9.37)mmHg,(94.16±8.91)mmHg,(116.22±11.34)mmHg],24-hour urine protein[(0.19±0.04)g,(1.20±0.23)g,(2.35±0.41)g]and serum CKLF1 level[(29.63±4.17)ng/L,(31.65±3.61)ng/L,(34.77±6.75)ng/L]of pregnant women in control group,mild PE group and severe PE group were increased successively(P<0.05),while serum CTRP6 level[(645.29±61.40)μg/L,(612.63±33.98)μg/L,(510.23±39.79)μg/L]was decreased successively(P<0.05);Pearson correlation analysis showed that there was a negative correlation between serum CTRP6 and CKLF1 in PE patients(r=−0.45,P<0.001);the area under the curve(AUC)of serum CTRP6 and CKLF1 for diagnosis of PE was 0.74 and 0.68,respectively,with sensitivity of 62.9%and 64.3%respectively,specificity of 37.2%and 68.5%respectively;the AUC of combined diagnosis of PE was 0.87,and its sensitivity and specificity were 71.4%and 68.5%respectively;multivariate logistic regr

关 键 词：先兆子痫 C1q/肿瘤坏死因子相关蛋白 趋化素样因子-1 孕妇 妊娠期 

分 类 号：R714.2[医药卫生—妇产科学]