清肝养血汤熏蒸联合揿针治疗肝肾阴虚型干眼症的疗效分析  

Clinical efficacy of Qinggan Yangxuetang fumigation combined with thumbtack needle for dry eye disease with pattern of liver and kidney Yin deficiency

作　　者：李雄 张雨歌 程联英 沈世英 荣晓凤[1] LI Xiong;ZHANG Yuge;CHENG Lianying;SHEN Shiying;RONG Xiaofeng(Department of Integrated Traditional Chinese and Western Medical,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Traditional Chinese Medical,The People'Hospital of Chongqing Nanchuan District,Chongqing 408400,China)

机构地区：[1]重庆医科大学附属第一医院中西医结合科,重庆400016 [2]重庆市南川区人民医院中医科,重庆408400

出　　处：《安徽医药》2025年第5期1023-1028,共6页Anhui Medical and Pharmaceutical Journal

基　　金：重庆市科卫联合医学科研项目(2022MSXM185)。

摘　　要：目的探讨清肝养血汤熏蒸结合揿针疗法治疗肝肾阴虚型睑板腺功能障碍干眼症的临床效果及安全性。方法选取2022年1月至2023年6月在重庆医科大学附属第一医院及重庆市南川区人民医院接受治疗的肝肾阴虚型睑板腺功能障碍干眼症病人120例,采用随机数字表法均分为两组,对照组(60例)接受常规睑板腺按摩治疗,观察组(60例)采用清肝养血汤熏蒸联合揿针治疗。比较两组病人临床疗效、中医证候积分、眼表疾病指数评分(OSDI)、免疫球蛋白G(IgG)、红细胞沉降率(ESR)、C反应蛋白(CRP)水平、泪液分泌量(SIT)、泪膜破裂时间(BUT)、睑板腺分泌功能评分、睑板腺分泌物性状评分、治疗不良反应发生情况。结果观察组有效率93.3%显著高于对照组73.7%(P<0.05);治疗后,观察组中医证候积分[(5.53±1.20)分比(6.33±2.51)分]、OSDI[(15.77±2.56)分比(21.53±4.79)分]、IgG[(17.21±3.65)g/L比(19.33±4.15)g/L]、CRP[(10.52±1.53)mg/L比(11.84±1.26)mg/L]、ESR水平[(16.70±12.53)mm/h比(25.07±17.92)mm/h]、睑板腺分泌功能评分[(1.27±0.52)分比(1.73±0.52)分]、睑板腺分泌物性状评分[(1.37±0.49)分比(1.87±0.51)分]均较对照组低(P<0.05);治疗后,观察组SIT[(10.73±1.55)mm/5 min比(6.33±2.51)mm/5 min]、BUT[(13.13±1.53)s比(8.27±1.53)s]均较对照组升高(P<0.05);观察组不良反应发生率6.7%显著低于对照组20%(P<0.05)。结论清肝养血汤熏蒸联合揿针治疗可显著提升病人临床疗效,改善病人的眼表症状及功能,且安全性高。Objective To observe the clinical efficacy and safety of Qinggan Yangxuetang fumigation combined with thumbtack needle for meibomian gland dysfunction(MGD)-related dry eye with pattern of liver kidney Yin deficiency.Methods A total of 120 eligible patients from the First Affiliated Hospital of Chongqing Medical University and the People's Hospital of Nanchuan District of Chongqing from January 2022 to June 2023 were evenly assigned into two groups,with 60 individuals allocated to the control group and an equal number to the observation group through a random assignment process.The control group received meibomian gland massage;and those in the observation group were treated with Qinggan Yangxuetang fumigation combined with thumbtack needle.The clinical efficacy,TCM syndrome score,Ocular Surface Disease Index(OSDI),immunoglobulinG(IgG),erythrocyte sedimentation rate(ESR),creactive Protein(CRP),tear secretion test(SIT),tear film break-up time(BUT),meibomian gland secretion function score,meibomian gland secretion character score,and adverse reactions after treatment of two groups were observed.Results The observation group demonstrated a significantly higher overall efficacy rate compared to the control group(93.3%vs.73.3%,P<0.05),respectively.After treatment,the observation group showed lower scores in the following parameters compared to the control group:TCM syndrome score[(5.53±1.20)points vs.(6.33±2.51)points],OSDI[(15.77±2.56)points vs.(21.53±4.79)points],IgG[(17.21±3.65)g/L vs.(19.33±4.15)g/L],CRP[(10.52±1.53)mg/L vs.(11.84±1.26)mg/L],ESR level[(16.70±12.53)mm/h vs.(25.07±17.92)mm/h],meibomian gland secretion function score[(1.27±0.52)points vs.(1.73±0.52)points],and meibomian gland secretion character score[(1.37±0.49)points vs.(1.87±0.51)points](P<0.05).After treatment,the observation group exhibited an increase in the following parameters compared to the control group:SIT[(10.73±1.55)mm/5 min vs.(6.33±2.51)mm/5 min]and BUT[(13.13±1.53)s vs.(8.27±1.53)s](P<0.05).The incidence of adverse r

关 键 词：干眼症 睑板腺 肝肾阴虚 中药熏蒸 揿针 临床疗效 

分 类 号：R276.7[医药卫生—中医五官科学]