机构地区:[1]湖北省汉川市人民医院新生儿科,湖北汉川431600
出 处:《河北医科大学学报》2025年第4期418-423,共6页Journal of Hebei Medical University
基 金:湖北省自然科学基金(2019CFB567)。
摘 要:目的探讨血清Clara细胞分泌蛋白16(Clara cell secretory protein 16,CC-16)、肺表面活性蛋白A(pulmonary surfactant protein A,SP-A)及氨基末端脑钠肽前体(N-terminal pro-B type natriuretic peptide,NT-proBNP)、白细胞介素17(interleukin-17,IL-17)在新生儿呼吸窘迫综合征(neonatal respiratory distress syndrome,NRDS)中的表达及意义。方法将2021年1月—2023年2月湖北省汉川市人民医院收治的NRDS患儿98例纳为NRDS组,其中轻度38例,中度33例,重度27例,另将同时期在我院出生的健康新生儿50例纳为健康组。比较2组CC-16、SP-A、NT-proBNP、IL-17水平;通过受试者工作特征曲线分析CC-16、SP-A、NT-proBNP、IL-17单独及各项联合评估NRDS的价值。比较不同病情严重程度NRDS患儿基线资料与CC-16、SP-A、NT-proBNP、IL-17水平;通过Spearman秩相关分析检验CC-16、SP-A、NT-proBNP、IL-17水平与NRDS病情严重程度的相关性。结果NRDS组CC-16、SP-A、NT-proBNP、IL-17水平[(60.21±3.85)mg/L、(74.96±6.35)mg/L、(5063.44±992.65)ng/L、(99.75±30.42)ng/L]明显高于健康组[(12.09±1.27)mg/L、(17.88±2.76)mg/L、(1872.49±502.51)ng/L、(58.82±15.73)ng/L],差异有统计学意义(P<0.05)。ROC曲线分析结果显示,CC-16、SP-A、NT-proBNP、IL-17评估NRDS的曲线下面积为0.845、0.870、0.846、0.885,各项联合评估NRDS的曲线下面积为0.927,敏感度为0.980。轻度组CC-16、SP-A、NT-proBNP、IL-17水平[(37.69±10.52)mg/L、(46.85±7.36)mg/L、(3472.57±295.14)ng/L、(39.86±12.45)ng/L]低于中度组[(52.37±16.24)mg/L、(72.81±8.06)mg/L、(4886.29±334.72)ng/L、(101.49±32.13)ng/L]和重度组[(85.13±14.44)mg/L、(97.23±12.37)mg/L、(6379.36±362.47)ng/L、(146.52±35.08)ng/L],中度组CC-16、SP-A、NT-proBNP、IL-17水平低于重度组,差异有统计学意义(P<0.05)。CC-16、SP-A、NT-proBNP、IL-17与NRDS病情严重程度之间呈正相关关系(r=0.549、0.574、0.607、0.563,均P<0.05)。结论CC-16、SP-A、NT-proBNP、IL-17在NRDS中表达水平升高,�Objective To explore the expression and significance of Clara cell secretory protein 16(CC-16),pulmonary surfactant protein A(SP-A),N-terminal pro-B type natriuretic peptide(NT-proBNP)and interleukin-17(IL-17)in neonatal respiratory distress syndrome(NRDS).Methods In total,98 children with NRDS admitted to Hanchuan People′s Hospital of Hubei Province from January 2021 to February 2023 were included in the NRDS group,including 38 mild cases,33 moderate cases and 27 severe cases.In addition,another 50 healthy newborns born in our hospital during the same period were included in the healthy group.The levels of CC-16,SP-A,NT-proBNP and IL-17 were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the value of CC-16,SP-A,NT-proBNP,and IL-17 alone and in combination in evaluating NRDS.The baseline data and levels of CC-16,SP-A,NT-proBNP and IL-17 in NRDS children with different severity were compared.Spearman rank correlation analysis was used to examine the correlation between CC-16,SP-A,NT-proBNP,IL-17 levels and the severity of NRDS.Results The levels of CC-16,SP-A,NT-proBNP and IL-17 in NRDS group[(60.21±3.85)mg/L,(74.96±6.35)mg/L,(5063.44±992.65)ng/L,(99.75±30.42)ng/L]were significantly higher than those in the healthy group[(12.09±1.27)mg/L,(17.88±2.76)mg/L,(1872.49±502.51)ng/L,(58.82±15.73)ng/L],with significant difference(P<0.05).The results of ROC curve analysis showed that the area under the ROC curve(AUC)of CC-16,SP-A,NT-proBNP and IL-17 for evaluating NRDS was 0.845,0.870,0.846 and 0.885,respectively;the AUC of the combination of the above indicators for evaluating NRDS was 0.927,and the sensitivity was 0.980.The levels of CC-16,SP-A,NT-proBNP and IL-17 in mild group[(37.69±10.52)mg/L,(46.85±7.36)mg/L,(3472.57±295.14)ng/L,(39.86±12.45)ng/L]were lower than those in moderate group[(52.37±16.24)mg/L,(72.81±8.06)mg/L,(4886.29±334.72)ng/L,(101.49±32.13)ng/L]and severe group[(85.13±14.44)mg/L,(97.23±12.37)mg/L,(6379.36±362.47)ng/L,(146.52±35.08)ng
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