标准四联疗法与序贯疗法对胃溃疡幽门螺杆菌阳性患者的临床应用效果比较  

The Clinical Treatment Efficacy of Standard Triple Therapy and Sequential Therapy in Helicobacter Pylori Positive Gastric Ulcer Patients:A Comparative Study

作　　者：杨琰琰 李小荣 李娟 YANG Yanyan;LI Xiaorong;LI Juan(Department of Gastroenterology,Affiliated Hospital of Gansu Medical College,Pingliang 744000,Gansu,China)

机构地区：[1]甘肃医学院附属医院消化内科,甘肃平凉744000

出　　处：《系统医学》2025年第4期14-17,共4页Systems Medicine

摘　　要：目的评估标准四联疗法、序贯疗法应用在胃溃疡(gastric ulcer,GU)幽门螺杆菌(helicobacter pylori,Hp)阳性患者中的应用效果及对临床症状评分、治疗总有效率的影响。方法非随机选取2022年1月—2023年12月甘肃医学院附属医院Hp阳性的78例GU患者为研究对象,按照治疗方式不同分为两组,各39例。对照组给予标准四联疗法,观察组给予序贯疗法,比较两组临床有效率、Hp根除率、临床症状评分、胃泌素(gastrin,GAS)和胃动素(motilin,MTL)、药物不良反应(adverse drug reaction,ADR)。结果观察组治疗总有效率为97.44%(38/39),高于对照组的79.49%(31/39),差异有统计学意义(χ^(2)=4.522,P<0.05)。观察组Hp根除率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组临床症状评分、GAS水平比对照组更低,MTL水平比对照组更高,差异有统计学意义(P均<0.05)。观察组ADR与对照组相比,差异无统计学意义(P>0.05)。结论对Hp阳性的GU患者实施序贯疗法,可以提高治疗总有效率、Hp根除率,降低临床症状评分,调节GAS、MTL水平,安全性良好,具有一定的临床借鉴意义。Objective To evaluate the effect of standard quadruple therapy and sequential therapy on Helicobacter pylori(Hp)positive patients with gastric ulcer(GU)and its effect on clinical symptom score and total effective rate of treatment.Methods From January 2022 to December 2023,seventy-eight GU patients with Hp positive in the Affiliated Hospital of Gansu Medical College were non-randomly selected as the research objects,and divided into two groups according to different treatment methods,with thirty-nine cases in each group.The control group was given standard quadruple therapy,and the observation group was given sequential therapy.The clinical effective rate,Hp eradication rate,clinical symptom score,gastrin(GAS)and motilin(MTL),and adverse drug reaction(ADR)were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.44%(38/39),which was higher than 79.49%(31/39)in the control group,and the difference was statistically significant(χ^(2)=4.522,P<0.05).The eradication rate of Hp in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the clinical symptom score and GAS level of the observation group was lower than control group,and the MTL level was higher than control group,the differences were statistically significant(all P<0.05).There was no significant difference in ADR between the observation group and the control group(P>0.05).Conclusion Sequential therapy for Hp-positive GU patients can improve the total effective rate of treatment,Hp eradication rate,reduce clinical symptom score,regulate GAS and MTL levels,and has good safety,which has certain clinical reference significance.

关 键 词：标准四联疗法 序贯疗法 胃溃疡 幽门螺杆菌 阳性 临床症状评分 治疗总有效率 

分 类 号：R4[医药卫生—临床医学]