司美格鲁肽联合阿托伐他汀对单纯性肥胖合并血脂异常患者进行治疗的效果分析  

Analysis of the Effect of Smeglutide Combined with Atorvastatin on the Treatment of Patients with Simple Obesity and Dyslipidemia

作　　者：仲英洁 翟霄燕 朱珠 彭晨 ZHONG Yingjie;ZHAI Xiaoyan;ZHU Zhu;PENG Chen(General Practice and Health Management Centre,Shanghai Jiahui International Hospital,Shanghai 200030,China)

机构地区：[1]上海嘉会国际医院全科及健康管理中心,上海200030

出　　处：《系统医学》2025年第4期23-26,共4页Systems Medicine

摘　　要：目的探讨单纯性肥胖合并血脂异常患者治疗中选择司美格鲁肽联合阿托伐他汀的疗效。方法非随机选取2023年3月—2024年4月上海嘉会国际医院收治的141例单纯性肥胖合并血脂异常患者为研究对象,按治疗方案不同分为两组。观察组(71例)给予司美格鲁肽+阿托伐他汀治疗,对照组(70例)给予阿托伐他汀治疗。对比两组不良反应发生情况、血脂水平、临床指标。结果两组患者不良反应发生率对比,差异无统计学意义(P>0.05)。治疗3个月后,两组患者的血脂水平均改善,观察组的总胆固醇为(4.52±0.12)mmol/L、甘油三酯(1.41±0.11)mmol/L、低密度脂蛋白胆固醇(3.21±0.48)mmol/L,低于对照组的(5.14±0.14)mmol/L、(1.62±0.12)mmol/L、(3.72±0.31)mmol/L;高密度脂蛋白胆固醇为(1.86±0.33)mmol/L,高于对照组的(1.52±0.31)mmol/L,差异有统计学意义(t=28.247、10.835、7.482、6.303,P均<0.05)。治疗3个月后,两组患者临床指标均改善,且观察组体重指数、腰围、臀围、体脂率均低于对照组,差异有统计学意义(P均<0.05)。结论单纯性肥胖合并血脂异常治疗中选择司美格鲁肽联合阿托伐他汀方案可改善血脂水平及体重指数,提高治疗有效性、安全性。Objective To investigate the efficacy of smeglutide combined with atorvastatin in the treatment of patients with simple obesity and dyslipidemia.Methods A total of 141 patients with simple obesity and dyslipidemia admitted to Shanghai Jiahui International Hospital from March 2023 to April 2024 were non-randomly selected as the research objects and divided into two groups according to different treatment schemes.The observation group(71 cases)was treated with smeglutide+atorvastatin,and the control group(70 cases)was treated with atorvastatin.The incidence of adverse reactions,blood lipid levels and clinical indicators were compared between the two groups.Results There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 3 months of treatment,the blood lipid levels of the two groups were improved.The total cholesterol,triglyceride and low density lipoprotein cholesterol in the observation group were(4.52±0.12)mmol/L,(1.41±0.11)mmol/L,(3.21±0.48)mmol/L,lower than(5.14±0.14)mmol/L,(1.62±0.12)mmol/L,(3.72±0.31)mmol/L in the control group,the high-density lipoprotein cholesterol was(1.86±0.33)mmol/L,which was higher than(1.52±0.31)mmol/L of the control group,and the differences were statistically significant(t=28.247,10.835,7.482,6.303,all P<0.05).After 3 months of treatment,the clinical indexes of the two groups were improved,and the body mass index,waist circumference,hip circumference and body fat rate of the observation group were lower than those of the control group,the differences were statistically significant(all P<0.05).Conclusion In the treatment of simple obesity complicated with dyslipidemia,the combination of smeglutide and atorvastatin can improve the blood lipid level and body mass index,and improve the efficacy and safety of treatment.

关 键 词：司美格鲁肽 阿托伐他汀 单纯性肥胖 血脂异常 体脂率 

分 类 号：R4[医药卫生—临床医学]