低分子肝素钙与重组人脑利钠肽联合治疗重症肺心病合并心力衰竭的临床效果分析  

Analysis of the Clinical Effect of Combined Treatment of Severe Pulmonary Heart Disease Combined with Heart Failure by Low Molecular Heparin Calcium and Recombinant Human Brain Lipotropic Peptide

作　　者：杨莉 YANG Li(Department of Critical Care Medicine,Heze Sixth People's Hospital,Heze 274000,Shandong,China)

机构地区：[1]菏泽市第六人民医院重症医学科,山东菏泽274000

出　　处：《系统医学》2025年第4期39-41,45,共4页Systems Medicine

摘　　要：目的研究低分子肝素钙联合重组人脑利钠肽治疗重症肺心病合并心力衰竭患者的效果。方法非随机选取菏泽市第六人民医院2021年3月—2023年5月收治的98例重症肺心病合并心力衰竭患者。按治疗方法分为两组,每组49例。对照组静脉推注重组人脑利钠肽,研究组在对照组基础上给予低分子量肝素钙。比较两组心功能指标、血流动力学指标与不良反应发生率。结果两组心功能指标、血流动力学指标比较,研究组优于对照组,差异有统计学意义(P均<0.05)。与对照组的16.33%(8/49)相比,研究组不良反应发生率4.08%(2/49)较低,差异有统计学意义(χ^(2)=4.009,P<0.05)。结论对于重症肺心病合并心力衰竭患者患者来说,应用低分子肝素钙联合重组人脑利钠肽治疗有助于改善心功能,维持血流动力学稳定,且并发症发生风险较低。Objective To study the effect of low molecular heparin calcium combined with recombinant human brain natriuretic peptide in the treatment of patients with severe pulmonary heart disease combined with heart failure.Methods Ninety-eight patients with severe pulmonary heart disease combined with heart failure admitted to Heze Sixth People's Hospital from March 2021 to May 2023 were non-randomly selected as study subjects.According to the treatment methods,the patients were grouped with forty-nine cases in each group.The control group was intravenously pushed recombinant human brain natriuretic peptide,and the study group was given low molecular weight heparin calcium on the basis of the control group.Cardiac function indexes,hemodynamic indexes and the incidence of adverse reactions were compared between the two groups.Results The level of cardiac function indexes and the hemodynamic indexes were better than those in the control group,and the differences were statistically significant(all P<0.05).Compared with 16.33%(8/49)in the control group,the incidence of adverse reactions in the study group 4.08%(2/49)was lower,and the difference was statistically significant(χ^(2)=4.009,P<0.05).Conclusion Treatment with low molecular heparin calcium combined with recombinant human brain natriuretic peptide in patients with severe pulmonary heart disease combined with heart failure contributes to the improvement of cardiac function,the maintenance of hemodynamic stability,and a lower risk of complications.

关 键 词：低分子肝素钙 重组人脑利钠肽 肺心病 心力衰竭 血流动力学 并发症 

分 类 号：R4[医药卫生—临床医学]