卡前列素氨丁三醇与麦角新碱分别联合缩宫素预防剖宫产产后出血效果观察  

Observation on the Effect of Carboprost Tromethamine and Ergometrine Combined with Oxytocin in Preventing Postpartum Hemorrhage after Cesarean Section

作　　者：李小燕 王丽 郭永利 LI Xiaoyan;WANG Li;GUO Yongli(Department of Obstetrics,Qianxinan People's Hospital,Xingyi 562400,Guizhou,China)

机构地区：[1]黔西南州人民医院产科,贵州兴义562400

出　　处：《系统医学》2025年第4期157-160,共4页Systems Medicine

摘　　要：目的探讨卡前列素氨丁三醇(carboprost tromethamine,CBT)与麦角新碱分别联合缩宫素在剖宫产产妇中的应用效果。方法回顾性选取2022年5月—2023年10月在黔西南州人民医院产科住院的112例剖宫产产妇的临床资料,按照不同治疗方法分为麦角新碱组与CBT组,各56例。麦角新碱组予以麦角新碱联合缩宫素,CBT组予以CBT联合缩宫素。对比两组临床疗效、出血情况、凝血功能、产后出血发生率、不良反应发生情况。结果CBT组治疗总有效率为98.21%(55/56),高于麦角新碱组的85.71%(48/56),差异有统计学意义(χ^(2)=4.350,P<0.05)。CBT组产后2、12、24 h出血量均少于麦角新碱组,差异有统计学意义(P均<0.05)。产后24 h,CBT组血浆凝血酶时间、活化部分凝血活酶时间、血浆凝血酶原时间、D-二聚体低于麦角新碱组,纤维蛋白原高于麦角新碱组,差异有统计学意义(P均<0.05)。组间产后出血发生率比较,差异有统计学意义(P<0.05);组间不良反应发生率相比,差异无统计学意义(P>0.05)。结论与麦角新碱相比,CBT与缩宫素联用止血效果好,可加强子宫收缩,改善凝血功能,降低产后出血发生率,安全性高。Objective To investigate the application effect of carboprost tromethamine(CBT)and ergometrine combined with oxytocin in cesarean section.Methods The clinical data of 112 parturients with cesarean section who were hospitalized in the Obstetrics Department of Qianxinan People's Hospital from May 2022 to October 2023 were retrospectively selected.According to different treatment methods,they were divided into ergometrine group and CBT group,with 56 cases in each group.The ergometrine group was given ergometrine combined with oxytocin,and the CBT group was given CBT combined with oxytocin.The clinical efficacy,bleeding,coagulation function,incidence of postpartum hemorrhage and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the CBT group was 98.21%(55/56),which was higher than 85.71%(48/56)in the ergometrine group,and the difference was statistically significant(χ^(2)=4.350,P<0.05).The amount of bleeding at 2,12 and 24 hours after delivery in the CBT group was less than that in the ergometrine group,and the difference was statistically significant(all P<0.05).At 24 hours after delivery,the plasma thrombin time,activated partial thromboplastin time,plasma prothrombin time and D-dimer in the CBT group were lower than those in the ergometrine group,and the fibrinogen was higher than that in the ergometrine group,and the difference was statistically significant(all P<0.05).There was significant difference in the incidence of PPH between the two groups(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with ergometrine,CBT combined with oxytocin has better hemostatic effect,can strengthens uterine contraction,improves coagulation function,reduces the incidence of postpartum hemorrhage,and has high safety.

关 键 词：产后出血 剖宫产 缩宫素 CBT 麦角新碱 临床疗效 

分 类 号：R714[医药卫生—妇产科学]