经鼻高流量湿化氧疗联合硝酸甘油注射液治疗急性左心衰竭的临床疗效分析  

Analysis of Clinical Efficacy of Nasal High-flow Humidified Oxygen Therapy Combined with Nitroglycerin Injection in the Treatment of Acute Left Heart Failure

作　　者：赵燕[1] 何瑾[1] 朱宾仁 ZHAO Yan;HE Jin;ZHU Binren(Department of Emergency,Zigong Fourth People′s Hospital,Sichuan Province,Zigong 643000,Sichuan,China)

机构地区：[1]四川省自贡市第四人民医院急诊科,四川自贡643000

出　　处：《系统医学》2025年第1期45-49,共5页Systems Medicine

摘　　要：目的探讨经鼻高流量湿化氧疗联合硝酸甘油注射液治疗急性左心衰竭的临床疗效。方法非随机选取四川省自贡市第四人民医院于2021年11月—2023年5月收治的104例急性左心衰竭患者为研究对象,按照治疗方法的不同分为对照组和观察组,每组52例。对照组给予常规治疗,观察组在对照组的基础上给予经鼻高流量湿化氧疗与入硝酸甘油注射液联合治疗。比较两组患者的血浆心肌损伤标志物水平、超声心动图参数以及血清指标。结果治疗后,观察组的肌钙蛋白I、肌钙蛋白T、肌酸激酶同工酶以及N末端B型脑钠肽前体分别为(12.74±3.19)ng/L、(7.01±1.73)ng/L、(10.84±2.51)U/L、(760.82±142.40)ng/L,均低于对照组的(19.92±4.17)ng/L、(11.71±2.86)ng/L、(16.19±3.15)U/L、(1054.75±188.96)ng/L,差异有统计学意义(t=9.862、10.140、9.578、8.958,P均<0.05)。两组患者的左室射血分数、每搏输出量以及二尖瓣流速比与治疗前比较均增加,且观察组高于对照组,左房容积指数与治疗前降低,且观察组的降低幅度高于对照组,差异有统计学意义(P均<0.05)。两组血清指标与治疗前比较均下降,且观察组低于对照组,差异有统计学意义(P均<0.05)。结论经鼻高流量湿化氧疗联合硝酸甘油注射液治疗可显著改善急性左心衰竭患者的心肌损伤标志物水平、心脏功能和血清指标,效果明显。Objective To investigate the clinical efficacy of nasal high-flow humidified oxygen therapy combined with nitroglycerin injection in the treatment of acute left heart failure.Methods A total of 104 patients with acute left heart failure admitted to the Fourth People′s Hospital of Zigong City,Sichuan Province from November 2021 to May 2023 were non-randomly selected as the research objects.According to different treatment methods,they were divided into control group and observation group,with 52 cases in each group.The control group was given routine treatment,and the observation group was treated with nasal high-flow humidified oxygen therapy combined with nitroglycerin injec⁃tion on the basis of the control group.The levels of plasma myocardial injury markers,echocardiographic parameters and serum indexes were compared between the two groups.Results After treatment,the levels of cardiac troponin I,cardiac troponin T,creatine kinase-MB and N-terminal pro-B-type natriuretic peptide in the observation group were(12.74±3.19)ng/L,(7.01±1.73)ng/L,(10.84±2.51)U/L and(760.82±142.40)ng/L,respectively,which were lower than(19.92±4.17)ng/L,(11.71±2.86)ng/L,(16.19±3.15)U/L and(1054.75±188.96)ng/L in the control group,the differ⁃ences were statistically significant (t=9.862, 10.140, 9.578, 8.958, all P<0.05). The left ventricular ejection fraction, stroke volume and early maximal ventricular filling velocity atrial maximal ventricular filling velocity of the two groups increased compared with those before treatment, and the observation group was higher than that of the control group. The left atrial volume index decreased compared with that before treatment, and the observation group was lower than that of the control group, the differences were statistically significant (all P<0.05). The serum indexes of the two groups were lower than those before treatment, and the decrease of the observation group was higher than that of the control group, the differences were statistically significant (all P<0.05). Conclusi

关 键 词：经鼻高流量湿化氧疗 硝酸甘油注射液 急性左心衰竭 临床疗效 

分 类 号：R4[医药卫生—临床医学]