氟马西尼联合纳洛酮用于急性苯二氮卓类药物中毒治疗的效果分析  

Effect Analysis of Flumazenil Combined with Naloxone in the Treatment of Acute Benzodiazepine Poisoning

作　　者：邵明斌 陈梅 洪鹤林 SHAO Mingbin;CHEN Mei;HONG Helin(Department of Emergency,The Second People′s Hospital of Guiyang,Guiyang 550081,Guizhou,China;Department of Outpatient and Emergency,Guiyang Public Health Treatment Center Huaguoyuan,Guiyang 550081,Guizhou,China)

机构地区：[1]贵阳市第二人民医院急诊科,贵州贵阳550081 [2]贵阳市公共卫生救治中心花果园门急诊,贵州贵阳550081

出　　处：《系统医学》2025年第1期126-128,133,共4页Systems Medicine

摘　　要：目的分析采用氟马西尼+纳洛酮联合治疗急性苯二氮卓类药物中毒患者的效果。方法非随机选取贵阳市第二人民医院于2023年1—12月收治的急性苯二氮卓类药物中毒的84例患者作为研究对象。根据不同的治疗方式进行分组,对照组采用纳洛酮治疗(n=41),观察组采用氟马西尼联合纳洛酮治疗(n=43)。对比两组患者的治疗效果、昏迷和镇静情况、临床指标、不良反应发生情况。结果对比两组患者的治疗总有效率,观察组较对照组更高,差异有统计学意义(P<0.05)。治疗30 min后,观察组格拉斯哥昏迷评分、改良警觉/镇静评分均高于对照组,差异有统计学意义(P均<0.05);观察组的药物起效时间为(22.18±3.33)min、症状消失时间为(43.11±5.34)min、催醒时间为(2.63±0.43)min、住院时间为(5.11±1.21)d,均短于对照组的(46.78±5.46)min、(80.23±6.44)min、(8.24±1.55)min、(8.13±2.34)d,差异有统计学意义(t=25.062、28.812、22.836、7.480,P均<0.05)。将两组患者的不良反应发生率进行对比,发现观察组较对照组更低,差异有统计学意义(P<0.05)。结论采用氟马西尼+纳洛酮联合治疗急性苯二氮卓类药物中毒患者具有积极意义,可明显改善患者昏迷情况,促进患者尽快清醒,安全性更高,增强患者整体疗效。Objective To analyze the effect of flumazenil combined with naloxone in the treatment of patients with acute benzodiazepine drug poisoning.Methods A total of eighty-four patients with acute benzodiazepine drug poisoning admitted to the Second People′s Hospital of Guiyang from January to December 2023 were non-randomly selected as the research objects.According to different treatment methods,the control group was treated with naloxone(n=41),and the observation group was treated with flumazenil combined with naloxone(n=43).The therapeutic effect,coma and sedation,clinical indicators and adverse reactions were compared between the two groups.Results Compared with the total effective rate of the two groups,the observation group was higher than the control group,and the difference was statistically significant(P<0.05).After 30 min of treatment,the Glasgow coma score and modified alertness/sedation score of the observation group were higher than those of the control group,and the differences were statistically significant(both P<0.05).The drug onset time score of the observation group was(22.18±3.33)min,the symptom disappearance time score was(43.11±5.34)min,the awakening time score was(2.63±0.43)min,and the hospitalization time score was(5.11±1.21)d,which were shorter than those of the control group(46.78±5.46)min,(80.23±6.44)min,(8.24±1.55)min,(8.13±2.34)d.The difference was statistically significant(t=25.062,28.812,22.836,7.480,all P<0.05).The incidence of adverse reactions in the two groups was compared,and it was found that the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of flumazenil+naloxone in the treatment of patients with acute benzodiazepine drug poisoning has positive significance.It can significantly improve the coma of patients,promote patients to wake up as soon as possible,have higher safety,and enhance the overall efficacy of patients.

关 键 词：急性苯二氮卓类药物中毒 氟马西尼 纳洛酮 治疗效果 不良反应 

分 类 号：R4[医药卫生—临床医学]