溶血三项试验和血清总胆红素联合检测对新生儿溶血病的早期诊断价值  

The Value of the Combined Hemolytic Triple Test and Serum Total Biliru⁃bin in the Early Diagnosis of Hemolytic Disease in Newborns

作　　者：冯钊赞 邹蓓 邝慧玲 FENG Zhaozan;ZOU Bei;KUANG Huiling(Department of Laboratory,Foshan Nanhai District Sixth People′s Hospital,Foshan 528200,Guangdong,China)

机构地区：[1]佛山市南海区第六人民医院检验科,广东佛山528200

出　　处：《系统医学》2025年第1期145-147,共3页Systems Medicine

基　　金：佛山市自筹经费类科技创新项(2220001004956)。

摘　　要：目的分析联合使用溶血三项试验和血清总胆红素检测诊断新生儿溶血病的价值。方法非随机选取2022年9月—2023年5月佛山市南海区第六人民医院收治的80例疑似溶血病患儿为研究对象,均进行溶血三项试验和血清总胆红素检测,将临床结果作为金标准,分析溶血三项试验和血清总胆红素单一及联合检测的诊断效能。结果临床综合诊断阳性50例、阴性30例。联合检测的kappa值为0.840,高于溶血三项试验和血清总胆红素单一检测。联合检测的准确度、灵敏度、特异度、阳性预测值和阴性预测值分别为92.50%(74/80)、94.00%(47/50)、90.00%(27/30)、94.00%(47/50)、90.00%(27/30),均高于溶血三项试验的78.75%(63/80)、82.00%(41/50)、73.33%(22/30)、83.67%(41/49)、70.97%(22/31)和血清总胆红素单一检测的78.75%(63/80)、80.00%(40/50)、76.67%(23/30)、85.11%(40/47)、69.70%(23/33),差异有统计学意义(χ^(2)=14.742、10.557、11.847、15.749、16.321,P均<0.05)。结论溶血三项试验和血清总胆红素联合检测诊断新生儿溶血有较高的诊断效能。Objective To analyze the value of the combined use of the hemolytic triple test and the serum total biliru⁃bin test for the diagnosis of hemolytic disease of the newborn.Methods Eighty children with suspected hemolytic dis⁃ease admitted to Foshan Nanhai District Sixth People′s Hospital from September 2022 to May 2023 were non-randomly selected as the study subjects,and all of them underwent hemolytic triple test and serum total bilirubin test,and the clinical results were used as the gold standard to analyze the diagnostic efficacy of the hemolytic triple test and the serum total bilirubin single and combined test.Results The combined clinical diagnosis was positive in fifty cases and negative in thirty cases.The kappa value of the combined test was 0.840,which was higher than those of the triple test for hemolysis and the serum total bilirubin.The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of the combined test were 92.50%(74/80),94.00%(47/50),90.00%(27/30),94.00%(47/50),90.00%(27/30),which were higher than 78.75%(63/80),82.00%(41/50),73.33%(22/30),83.67%(41/49),70.97%(22/31)of hemolysis three tests and 78.75%(63/80),80.00%(40/50),76.67%(23/30),85.11%(40/47),69.70%(23/33)of serum total bilirubin single detection,and the differences were statistically significance(χ^(2)=14.742,10.557,11.847,15.749,16.321,all P<0.05).Conclusion The combination of three hemolytic tests and serum total bilirubin has a high diagnostic efficacy in the diagnosis of hemolysis in newborns.

关 键 词：溶血三项试验 血清总胆红素 新生儿 溶血病 

分 类 号：R446[医药卫生—诊断学]