Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens  

作　　者：Patrick Fernandes Rodrigues 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2025年第4期718-718,共1页

摘　　要：The intestinal immune system maintains tolerance to harmless food proteins and gut microbiota through peripherally derived RORγt+Tregs(pTregs),which prevent food intolerance and inflammatory bowel disease.Recent studies suggested that RORγt+antigen-presenting cells(APCs),which encompass rare dendritic cell(DC)subsets and type 3 innate lymphoid cells(ILC3s),are key to pTreg induction.Here,we developed a mouse with reduced RORγt+APCs by deleting a specific cis-regulatory element of Rorc encoding RORγt.Single-cell RNA sequencing and flow cytometry analyses confirmed the depletion of a RORγt+DC subset and ILC3s.These mice showed a secondary reduction in pTregs,impaired tolerance to oral antigens,and an increase in T helper(Th)2 cells.Conversely,ILC3-deficient mice showed no pTregs or Th2 cell abnormalities.Lineage tracing revealed that RORγt+DCs share a lymphoid origin with ILC3s,consistent with their similar phenotypic traits.These findings highlight the role of lymphoid RORγt+DCs in maintaining intestinal immune balance and preventing conditions like food allergies.

关 键 词：regulatory T cells inflammatory bowel diseaserecent dendritic cells type innate lymphoid cells ilc s ror t positive antigen presenting cells gut microbiota intestinal immune system food proteins 

分 类 号：R392[医药卫生—免疫学]